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1. WO2016146516 - NANOPARTICLES COMPRISING A STABILIZED BORONIC ACID COMPOUND

Publication Number WO/2016/146516
Publication Date 22.09.2016
International Application No. PCT/EP2016/055271
International Filing Date 11.03.2016
IPC
A61K 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61K 9/51 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules
51Nanocapsules
A61K 31/69 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
69Boron compounds
A61K 9/107 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
107Emulsions
CPC
A61K 31/69
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
69Boron compounds
A61K 38/05
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
05Dipeptides
A61K 9/0019
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
A61K 9/1075
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
107Emulsions ; ; Emulsion preconcentrates; Micelles
1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
A61K 9/145
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
145with organic compounds
A61K 9/5123
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules ; having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
51Nanocapsules; Nanoparticles;
5107Excipients; Inactive ingredients
5123Organic compounds, e.g. fats, sugars
Applicants
  • LEON-NANODRUGS GMBH [DE]/[DE]
Inventors
  • MÜHLHÖLZL-ODÖRFER, Kathrin Ines
  • HORSTKOTTE, Elke
  • WEITENSTEINER, Sabine
  • SOLE FONT, Isabel
  • TÜRELI, Akif Emre
Agents
  • MEISSNER BOLTE PATENTANWÄLTE RECHTSANWÄLTE PARTNERSCHAFT MBB
Priority Data
10 2015 103 873.017.03.2015DE
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NANOPARTICLES COMPRISING A STABILIZED BORONIC ACID COMPOUND
(FR) NANOPARTICULES COMPRENANT UN COMPOSÉ D'ACIDE BORONIQUE STABILISÉ
Abstract
(EN)
The present invention provides nanoparticles comprising at least one boronic acid compound and at least one stabilizing agent for the at least one boronic acid compound and/or a reaction product of the at least one boronic acid compound and the at least one stabilizing agent, whereby the nanoparticles have a particle size of about 10 to about 1000 nm. The present invention also provides a pharmaceutical composition comprising these nanoparticles and a method for the preparation of these nanoparticlesand the respective pharmaceutical compositions.In addition, the present invention provides nanoparticles and pharmaceutical compositions for the treatment of several disorders, especially multiple myeloma, preferably by parenteral administration.
(FR)
La présente invention concerne des nanoparticules comprenant au moins un composé d'acide boronique et au moins un agent de stabilisation pour l'au moins un composé d'acide boronique et/ou un produit de réaction de l'au moins un composé d'acide boronique et l'au moins un agent de stabilisation, les nanoparticules ayant une taille particulaire comprise entre environ 10 nm et environ 1 000 nm. La présente invention concerne également une composition pharmaceutique comprenant ces nanoparticules et une méthode pour la préparation de ces nanoparticules et des compositions pharmaceutiques respectives. De plus, la présente invention concerne des nanoparticules et des compositions pharmaceutiques pour le traitement de plusieurs affections, en particulier le myélome multiple, de préférence par administration par voie parentérale.
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