Processing

Please wait...

Settings

Settings

Goto Application

1. WO2016145041 - SYSTEMS AND METHODS FOR RELAY IONIZATION

Note: Text based on automatic Optical Character Recognition processes. Please use the PDF version for legal matters

[ EN ]

What is claimed is:

1. A system for analyzing a sample, the system comprising:

an ion source that generates ions;

a sample emitter configured to hold a sample; and

a mass spectrometer;

wherein the system is configured such that the ions generated by the ion source are directed to interact with the sample emitter in order to cause the sample to be discharged from the sample emitter and into the mass spectrometer.

2. The system according to claim 1, wherein the sample emitter is a hollow body and the sample is held within the hollow body.

3. The system according to claim 2, wherein a proximal portion of the hollow body is open ended and the ions from the ion source are directed to interact with and enter a proximal end of the hollow body, thereby causing the sample to be discharged from a distal end of the sample emitter and into the mass spectrometer.

4. The system according to claim 2, wherein a proximal portion of the hollow body is sealed and the ions from the ion source are directed to interact with the proximal end of the hollow body, thereby causing the sample to be discharged from a distal end of the sample emitter and into the mass spectrometer.

5. The system according to claim 1, wherein the sample emitter is a solid body and the sample is held on an exterior portion of the solid body.

6. The system according to claim 5, wherein the system is configured such that the ions from the ion source are directed to interact with a proximal end of the solid body, thereby causing the sample to be discharged from a distal end of the sample emitter and into the mass spectrometer.

7. The system according to claim 1, wherein the sample emitter is selected from the group consisting of: a hollow capillary in which a proximal and distal end are open; a hollow capillary in which a proximal end is sealed and a distal end is open; a steel needle comprising an inner bore; a solid steel needle; a porous material; and a combination thereof.

8. The system according to claim 1, wherein the ion source is an electrospray source.

9. The system according to claim 1, wherein the ion source is an plasma discharge source.

10. The system according to claim 1, wherein the mass spectrometer is a bench-top or miniature mass spectrometer.

11. A method for analyzing a sample, the method comprising:

generating ions from an ion source;

directing the ions to interact with a sample emitter comprising a sample in order to cause the sample to be discharged from the sample emitter; and

analyzing the discharged sample in a mass spectrometer.

12. The method according to claim 11, wherein the sample emitter is a hollow body and the sample is held within the hollow body.

13. The method according to claim 12, wherein a proximal portion of the hollow body is open ended and the ions from the ion source are directed to interact with and enter a proximal end of the hollow body, thereby causing the sample to be discharged from a distal end of the sample emitter and into the mass spectrometer.

14. The method according to claim 12, wherein a proximal portion of the hollow body is sealed and the ions from the ion source are directed to interact with the proximal end of the hollow body, thereby causing the sample to be discharged from a distal end of the sample emitter and into the mass spectrometer.

15. The method according to claim 11, wherein the sample emitter is a solid body and the sample is held on an exterior portion of the solid body.

16. The method according to claim 15, wherein the ions from the ion source are directed to interact with a proximal end of the solid body, thereby causing the sample to be discharged from a distal end of the sample emitter and into the mass spectrometer.

17. The method according to claim 11, wherein the sample emitter is selected from the group consisting of: a hollow capillary in which a proximal and distal end are open; a hollow capillary in which a proximal end is sealed and a distal end is open; a steel needle comprising an inner bore; a solid steel needle; a porous material; and a combination thereof.

18. The method according to claim 11, wherein the ion source is an electrospray source.

19. The method according to claim 11, wherein the ion source is an plasma discharge source.

20. The method according to claim 11, wherein the sample is a biological sample.