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1. WO2016144996 - METHOD FOR IDENTIFYING DISEASE-ASSOCIATED CDR3 PATTERNS IN AN IMMUNE REPERTOIRE

Publication Number WO/2016/144996
Publication Date 15.09.2016
International Application No. PCT/US2016/021430
International Filing Date 09.03.2016
IPC
C12Q 1/04 2006.01
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12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
02involving viable microorganisms
04Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
C12Q 1/68 2006.01
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12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
C40B 30/02 2006.01
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40COMBINATORIAL TECHNOLOGY
BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
30Methods of screening libraries
02In silico screening
CPC
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1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
02involving viable microorganisms
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C12Q 1/68
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68involving nucleic acids
C12Q 1/6881
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1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6881for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
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1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
C12Q 2600/156
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2600Oligonucleotides characterized by their use
156Polymorphic or mutational markers
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12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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2600Oligonucleotides characterized by their use
172Haplotypes
Applicants
  • IREPERTOIRE, INC. [US]/[US]
Inventors
  • HAN, Jian
Agents
  • PARKER, Matthew, J.
Priority Data
62/130,51209.03.2015US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD FOR IDENTIFYING DISEASE-ASSOCIATED CDR3 PATTERNS IN AN IMMUNE REPERTOIRE
(FR) PROCÉDÉ D'IDENTIFICATION DE MOTIFS CDR3 ASSOCIÉS À UNE MALADIE DANS UN RÉPERTOIRE IMMUNITAIRE
Abstract
(EN)
The present disclosure generally pertains to a method for developing diagnostic tests that are based on the immune response and the resulting immune repertoire. The presently disclosed method increases the signal and reduces the background to allow the identification of shared CDR3s that can be used to produce a disease signature. The presently disclosed method may be used to develop a diagnostic test for different diseases including, but not limited to, cancer, autoimmune disease, inflammatory disease and infectious disease.
(FR)
De manière générale, la présente invention concerne un procédé visant à développer des tests diagnostiques qui sont basés sur la réponse immunitaire et le répertoire immunitaire obtenu. Le procédé de la présente invention augmente le signal et réduit le bruit de fond afin de permettre l'identification de CDR3 partagés qui peuvent être utilisés pour produire une signature de maladie. Le procédé de la présente invention peut être utilisé pour développer un test diagnostique pour différentes maladies comprenant notamment, mais pas exclusivement, le cancer, une maladie auto-immune, une maladie inflammatoire et une maladie infectieuse.
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