WO2016144889 PLATINUM PRODRUGS AND METHODS OF MAKING AND USING THEREOF

Settings

Stemming

Single Family Member

Include NPL

Feedback

Goto Application

Publication Number WO/2016/144889

Publication Date 15.09.2016

International Application No. PCT/US2016/021223

International Filing Date 07.03.2016

IPC

CPC

View more classifications

View less classifications

Applicants

UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. [US]/[US]

Inventors

SHANTA, Dhar
RAKESH, Pathak

Agents

CURFMAN, Christopher L.

Priority Data

62/129,364

06.03.2015

Publication Language English (en)

Filing Language English (EN)

Designated States

View all

Title

(EN) PLATINUM PRODRUGS AND METHODS OF MAKING AND USING THEREOF

(FR) PROMÉDICAMENTS AU PLATINE ET PROCÉDÉS POUR LES PRÉPARER ET LES UTILISER

Abstract

(EN) Disclosed herein are prodrugs of platinum containing anticancer agents such as cisplatin that contain an alkylating moiety. Upon administration, the prodrugs release the platinum containing anticancer agent and the alkylating agent, which can form an adduct with DNA or can protect the platinum containing agent from removal. The disclosed prodrugs can be used to treat various cancers, including cisplatin resistant cancers.

(FR) La présente invention concerne des promédicaments d'agents anticancéreux contenant du platine, tels que le cisplatine, qui contiennent une fraction d'alkylation. Lors de l'administration, les promédicaments libèrent l'agent anticancéreux contenant du platine et l'agent d'alkylation, qui peut former un produit d'addition avec l'ADN ou peut protéger l'agent contenant du platine d'une élimination. Les promédicaments selon l'invention peuvent être utilisés pour traiter divers cancers, y compris les cancers résistant au cisplatine.

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9	Medicinal preparations characterised by special physical form
48	Preparations in capsules, e.g. of gelatin, of chocolate
50	Microcapsules
51	Nanocapsules

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435	having six-membered rings with one nitrogen as the only ring hetero atom
44	Non-condensed pyridines; Hydrogenated derivatives thereof
445	Non-condensed piperidines, e.g. piperocaine
4523	containing further heterocyclic ring systems
4545	containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
28	Compounds containing heavy metals
282	Platinum compounds

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9	Medicinal preparations characterised by special physical form
48	Preparations in capsules, e.g. of gelatin, of chocolate
50	Microcapsules
51	Nanocapsules

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435	having six-membered rings with one nitrogen as the only ring hetero atom
44	Non-condensed pyridines; Hydrogenated derivatives thereof
445	Non-condensed piperidines, e.g. piperocaine
4523	containing further heterocyclic ring systems
4545	containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine

Processing

National Phase Entries

Authority File

Settings

Feedback

Goto Application

1. WO2016144889 - PLATINUM PRODRUGS AND METHODS OF MAKING AND USING THEREOF

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
F	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
15	Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
0006	compounds of the platinum group
0086	Platinum compounds
0093	without a metal-carbon linkage

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9	Medicinal preparations characterised by special physical form
48	Preparations in capsules, e.g. of gelatin, of chocolate
50	Microcapsules ; having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
51	Nanocapsules; Nanoparticles;
5107	Excipients; Inactive ingredients
513	Organic macromolecular compounds; Dendrimers
5146	obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
5153	Polyesters, e.g. poly(lactide-co-glycolide)

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9	Medicinal preparations characterised by special physical form
48	Preparations in capsules, e.g. of gelatin, of chocolate
50	Microcapsules ; having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
51	Nanocapsules; Nanoparticles;
5107	Excipients; Inactive ingredients
513	Organic macromolecular compounds; Dendrimers
5146	obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
5153	Polyesters, e.g. poly(lactide-co-glycolide)