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1. WO2016144889 - PLATINUM PRODRUGS AND METHODS OF MAKING AND USING THEREOF

Publication Number WO/2016/144889
Publication Date 15.09.2016
International Application No. PCT/US2016/021223
International Filing Date 07.03.2016
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
50
Microcapsules
51
Nanocapsules
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
445
Non-condensed piperidines, e.g. piperocaine
4523
containing further heterocyclic ring systems
4545
containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
28
Compounds containing heavy metals
282
Platinum compounds
A61K 9/51 (2006.01)
A61K 31/4545 (2006.01)
A61K 31/282 (2006.01)
CPC
A61K 31/282
A61K 31/44
A61K 9/127
A61K 9/14
A61K 9/51
A61K 9/5153
Applicants
  • UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. [US/US]; 819 Boyd Graduate Studies Research Center Athens, Georgia 30602-7411, US
Inventors
  • SHANTA, Dhar; US
  • RAKESH, Pathak; US
Agents
  • CURFMAN, Christopher L.; US
Priority Data
62/129,36406.03.2015US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PLATINUM PRODRUGS AND METHODS OF MAKING AND USING THEREOF
(FR) PROMÉDICAMENTS AU PLATINE ET PROCÉDÉS POUR LES PRÉPARER ET LES UTILISER
Abstract
(EN)
Disclosed herein are prodrugs of platinum containing anticancer agents such as cisplatin that contain an alkylating moiety. Upon administration, the prodrugs release the platinum containing anticancer agent and the alkylating agent, which can form an adduct with DNA or can protect the platinum containing agent from removal. The disclosed prodrugs can be used to treat various cancers, including cisplatin resistant cancers.
(FR)
La présente invention concerne des promédicaments d'agents anticancéreux contenant du platine, tels que le cisplatine, qui contiennent une fraction d'alkylation. Lors de l'administration, les promédicaments libèrent l'agent anticancéreux contenant du platine et l'agent d'alkylation, qui peut former un produit d'addition avec l'ADN ou peut protéger l'agent contenant du platine d'une élimination. Les promédicaments selon l'invention peuvent être utilisés pour traiter divers cancers, y compris les cancers résistant au cisplatine.
Also published as
Latest bibliographic data on file with the International Bureau