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1. WO2016141889 - NOVEL TRIAZOLOPYRIMIDINE DERIVATIVE AND USE THEREOF

Publication Number WO/2016/141889
Publication Date 15.09.2016
International Application No. PCT/CN2016/076118
International Filing Date 11.03.2016
IPC
C07D 487/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 317/44 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
317Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
08having the hetero atoms in positions 1 and 3
44ortho- or peri-condensed with carbocyclic rings or ring systems
C07D 405/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
A61K 31/519 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
A61P 7/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
A61P 9/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
10for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
CPC
A61K 31/519
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
C07D 317/44
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
317Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
08having the hetero atoms in positions 1 and 3
44ortho- or peri-condensed with carbocyclic rings or ring systems
C07D 405/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 487/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • 四川海思科制药有限公司 SICHUAN HAISCO PHARMACEUTICAL CO., LTD. [CN]/[CN]
  • 广州诺威生物技术有限公司 GUANGZHOU NORWICH BIOLOGICAL TECHNOLOGY CO., LTD. [CN]/[CN]
Inventors
  • 袁道义 YUAN, Daoyi
  • 赵雄 ZHAO, Xiong
  • 陈真 CHEN, Zhen
  • 李学超 LI, Xuechao
  • 彭丹 PENG, Dan
  • 欧兴蓉 OU, Xingrong
  • 程鹤 CHENG, He
  • 罗杰 LUO, Jie
  • 严庞科 YAN, Pangke
  • 宫爱申 GONG, Aishen
  • 向志祥 XIANG, Zhixiang
  • 王明霞 WANG, Mingxia
  • 刘国强 LIU, Guoqiang
  • 王庚禹 WANG, Gengyu
Agents
  • 北京知元同创知识产权代理事务所(普通合伙) BEIJING ORIGINTELLIGENCE IP LAW FIRM
Priority Data
201510111164.612.03.2015CN
201610086808.516.02.2016CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) NOVEL TRIAZOLOPYRIMIDINE DERIVATIVE AND USE THEREOF
(FR) NOUVEAU DÉRIVÉ TRIAZOLOPYRIMIDINE ET SON UTILISATION
(ZH) 一种新型三唑并嘧啶衍生物及其应用
Abstract
(EN)
Provided are a novel triazolopyrimidine derivative represented by formula II, crystal form and preparation method thereof, and use thereof in the preparation of medicine for resisting coagulation and thrombus, treating or preventing cerebral ischemia diseases, or improving sleep.
(FR)
L'invention concerne un nouveau dérivé triazolopyrimidine représenté par la formule II, sa forme cristalline et son procédé de préparation, ainsi que son utilisation dans la préparation d'un médicament permettant de résister à la coagulation et au thrombus, permettant de traiter ou de prévenir les maladies ischémiques cérébrales, ou permettant d'améliorer le sommeil.
(ZH)
本发明提供了一种式Ⅱ所示的新型三唑并嘧啶衍生物及其晶型和制备方法,以及它们在制备抗凝血、抗血栓、治疗或预防脑缺血性疾病或改善睡眠的药物中的应用。
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