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1. WO2016141204 - METHODS FOR QUANTITATION OF INSULIN LEVELS BY MASS SPECTROMETRY

Publication Number WO/2016/141204
Publication Date 09.09.2016
International Application No. PCT/US2016/020723
International Filing Date 03.03.2016
IPC
G01N 30/72 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
02Column chromatography
62Detectors specially adapted therefor
72Mass spectrometers
G01N 33/68 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
G01N 27/64 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
27Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means
62by investigating the ionisation of gases; by investigating electric discharges, e.g. emission of cathode
64using wave or particle radiation to ionise a gas, e.g. in an ionisation chamber
C07K 14/47 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
C07K 14/62 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
575Hormones
62Insulins
CPC
G01N 2030/8813
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography ; or field flow fractionation;
02Column chromatography
88Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
8809analysis specially adapted for the sample
8813biological materials
G01N 2333/47
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
435from animals; from humans
46from vertebrates
47Assays involving proteins of known structure or function as defined in the subgroups
G01N 2333/62
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
435from animals; from humans
575Hormones
62Insulins
G01N 2800/042
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
04Endocrine or metabolic disorders
042Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
G01N 30/72
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography ; or field flow fractionation;
02Column chromatography
62Detectors specially adapted therefor
72Mass spectrometers
G01N 33/49
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
483Physical analysis of biological material
487of liquid biological material
49Blood
Applicants
  • QUEST DIAGNOSTICS INVESTMENTS LLC [US]/[US]
Inventors
  • TAYLOR, Steven W.
  • MCPHUAL, Michael
  • REITZ, Richard E.
  • CHEN, Zhaohui
  • CLARKE, Nigel J.
Agents
  • KIM, Joshua E.
Priority Data
62/127,77003.03.2015US
62/128,23604.03.2015US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS FOR QUANTITATION OF INSULIN LEVELS BY MASS SPECTROMETRY
(FR) PROCÉDÉS DE QUANTIFICATION DE NIVEAUX D'INSULINE PAR SPECTROMÉTRIE DE MASSE
Abstract
(EN)
Methods are described for determining the amount of insulin in a sample. Provided herein are mass spectrometric methods for detecting and quantifying insulin and C-peptide in a biological sample utilizing enrichment and/or purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques. Also provided herein are mass spectrometric methods for detecting and quantifying insulin and b-chain in a biological sample utilizing enrichment and/or purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.
(FR)
L'invention concerne des procédés de détermination de la quantité d'insuline dans un échantillon. Les procédés selon l'invention sont des procédés de spectrométrie de masse adaptés pour détecter et quantifier l'insuline et le C-peptide dans un échantillon biologique au moyen de procédés d'enrichissement et/ou de purification combinés à des techniques de spectrométrie de masse en tandem ou des techniques de spectrométrie de masse de résolution/précision élevées. L'invention concerne également des procédés de spectrométrie de masse adaptés pour détecter et quantifier l'insuline et la chaîne B dans un échantillon biologique au moyen de procédés d'enrichissement et/ou de purification combinés à des techniques de spectrométrie de masse en tandem ou des techniques de spectrométrie de masse de résolution/précision élevées.
Latest bibliographic data on file with the International Bureau