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1. WO2016139212 - TRIAZOLOPYRIDINE COMPOUNDS AND METHODS OF USE THEREOF

Publication Number WO/2016/139212
Publication Date 09.09.2016
International Application No. PCT/EP2016/054343
International Filing Date 02.03.2016
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
437
the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
C07D 471/04 (2006.01)
A61K 31/437 (2006.01)
A61P 29/00 (2006.01)
CPC
C07D 471/04
C07D 471/10
C07D 519/00
Applicants
  • F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 4070 Basel, CH (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW)
  • GENENTECH, INC. [US/US]; 1 DNA Way South San Francisco, California 94080, US (US)
Inventors
  • CHENG, Yun-Xing; CN
  • GOODACRE, Simon Charles; GB
  • LI, Wei; CN
  • RAY, Nicholas Charles; GB
  • ZAK, Mark Edward; US
Agents
  • SCHIRLIN, Julien; CH
Priority Data
62/128,23404.03.2015US
62/134,83818.03.2015US
PCT/CN2016/07228727.01.2016CN
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TRIAZOLOPYRIDINE COMPOUNDS AND METHODS OF USE THEREOF
(FR) COMPOSÉS DE TRIAZOLOPYRIDINE, ET PROCÉDÉS D'UTILISATION DE CEUX-CI
Abstract
(EN)
Provided are triazolopyridine compounds that are inhibitors of JAK kinase, such as JAK1, compositions containing these compounds and methods for treating diseases mediated by a JAK kinase. In particular, provided are compounds of formula (I), stereoisomers, tautomers, solvates, prodrugs or pharmaceutically acceptable salts thereof, where R1a, R1b, R1c, R2, R3, R4 and R are defined herein, pharmaceutical compositions comprising the compound and a pharmaceutically acceptable carrier, adjuvant or vehicle, methods of using the compound or composition in therapy, for example, for treating a disease or condition mediated by a JAK kinase in a patient.
(FR)
La présente invention concerne des composés pyrazolylaminopyridine qui sont des inhibiteurs de la kinase JAK, tels que JAK1, des compositions contenant ces composés et des procédés pour le traitement de maladies médiées par la kinase JAK. En particulier, l'invention concerne des composés de formule (I), leurs stéréoisomères, tautomères, solvates, promédicaments ou sels pharmaceutiquement acceptables; R1a, R1b, R1c, R2, R3, R4 et R étant tels que définis dans la description, des compositions pharmaceutiques comprenant le composé et un excipient, un adjuvant ou véhicule pharmaceutiquement acceptable, des procédés d'utilisation dudit composé ou de ladite composition en thérapie, par exemple pour le traitement d'une maladie ou d'un trouble médié par la kinase JAK chez un patient.
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