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1. WO2016137131 - SOFT CAPSULE COMPOSITION

Publication Number WO/2016/137131
Publication Date 01.09.2016
International Application No. PCT/KR2016/000999
International Filing Date 29.01.2016
IPC
A61K 9/48 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
A61K 9/50 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules
A61K 47/38 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
38Cellulose; Derivatives thereof
CPC
A61K 47/38
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
38Cellulose; Derivatives thereof
A61K 9/48
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
A61K 9/4816
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
4816Wall or shell material
A61K 9/4866
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
4841Filling excipients; Inactive ingredients
4866Organic macromolecular compounds
A61K 9/50
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules ; having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
Applicants
  • 김재훈 KIM, Jae-hun [KR]/[KR]
Inventors
  • 김재훈 KIM, Jae-hun
Agents
  • 박용민 PARK, Yong-min
Priority Data
10-2015-002804027.02.2015KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) SOFT CAPSULE COMPOSITION
(FR) COMPOSITION DE CAPSULE MOLLE
(KO) 연질 캡슐 조성물
Abstract
(EN)
The present invention relates to a soft capsule composition comprising a film-forming agent in the form of a water-soluble cellulose ether, a gelling agent in the form of iota carrageenan, an auxiliary gelling agent in the form of an organic-based calcium salt, a plasticizer in the form of glycerol, a disintegration-promoting agent in the form of silicon dioxide and distilled water. According to the present invention, when a soft capsule is to be moulded, energy is reduced as the gelling temperature of a film solution is lowered, and it is possible to perform moulding work over a long time as a resilient wet film can be produced even if the film solution is stored over a long time. Consequently, the moulding workability of the soft capsule is improved. Also, according to the present invention, it is possible to provide a soft capsule having outstanding disintegrability despite also having outstanding resilience.
(FR)
La présente invention concerne une composition de capsule molle comprenant un agent filmogène sous la forme d'un éther de cellulose soluble dans l'eau, un agent gélifiant sous la forme de carraghénane iota, un agent de gélification auxiliaire sous la forme d'un sel de calcium d'origine organique, un plastifiant sous la forme de glycérol, un agent favorisant la désintégration sous la forme de dioxyde de silicium et de l'eau distillée. Selon la présente invention, lorsqu'une capsule molle doit être moulée, l'énergie est réduite lorsque la température de gélification d'une solution de film est abaissée, et il est possible d'effectuer une opération de moulage pendant une longue durée car un film humide résilient peut être produit même si la solution de film est stockée pendant une longue durée. En conséquence, l'aptitude au moulage de la capsule molle est améliorée. Ainsi, selon la présente invention, il est possible de préparer une capsule molle présentant une excellente capacité de désintégration tout en présentant également une excellente résilience.
(KO)
본 발명은, 피막 형성제로서 수용성 셀룰로오스 에테르, 겔화제로서 이오타카라기난, 겔화보조제로서 유기계 칼슘염, 가소제로서 글리세린, 붕해촉진제로서 이산화규소 및 정제수를 포함하여 이루어지는 연질 캡슐 조성물에 관한 것이다. 본 발명에 따르면 연질 캡슐을 성형할 때에, 피막용액의 겔화 온도가 낮아져 에너지가 절감되며, 피막용액을 장시간 보관하여도 탄성을 갖는 습윤필름을 제조할 수 있어 장시간 성형 작업을 할 수 있게 된다. 이에 따라 연질 캡슐의 성형 작업성이 향상된다. 또한, 본 발명에 따르면 탄성이 우수하면서도 붕해성도 우수한 연질 캡슐을 제공할 수 있다.
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