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1. WO2016136624 - IMMUNOMODULATOR AND USE OF SAME

Publication Number WO/2016/136624
Publication Date 01.09.2016
International Application No. PCT/JP2016/054884
International Filing Date 19.02.2016
IPC
A61K 31/716 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
716Glucans
A61P 11/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
02Nasal agents, e.g. decongestants
A61P 17/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
A61P 37/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
A61P 37/08 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
08Antiallergic agents
A61P 43/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
CPC
A61K 31/716
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
716Glucans
Applicants
  • 株式会社林原 HAYASHIBARA CO., LTD. [JP]/[JP]
Inventors
  • 櫻井 岳夫 SAKURAI Takeo
  • 谷口 美文 TANIGUCHI Yoshifumi
  • 渡邊 光 WATANABE Hikaru
Agents
  • 須磨 光夫 SUMA Mitsuo
Priority Data
2015-03508925.02.2015JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) IMMUNOMODULATOR AND USE OF SAME
(FR) IMMUNOMODULATEUR ET UTILISATION DE CE DERNIER
(JA) 免疫調節剤及びその用途
Abstract
(EN)
[Problem] To provide an immunomodulator, which can be orally ingested continuously in daily diet without a fear of side effects, and use of the same. [Solution] To solve the problem, provided is an immunomodulator comprising, as an active ingredient, a branched α-glucan mixture having characteristics (A) to (C): (A) having glucose as a constituting saccharide; (B) having a branched structure with a glucose polymerization degree of 1 or higher, said branched structure being bound, via a linkage other than an α-1,4 linkage, to the non-reducing end glucose residue positioned at one end of a linear glucan which has a glucose polymerization degree of 3 or higher and in which glucose molecules are linked together via α-1,4 linkages; and (C) forming isomaltose when digested by isomaltodextranase.
(FR)
L'invention vise à fournir un immunomodulateur qui puisse être ingéré de façon continue par voie orale dans le régime alimentaire quotidien sans crainte d'effets indésirables, et procédé d'utilisation de ce dernier. À cet effet, l'invention propose une solution qui concerne un immunomodulateur comprenant, en tant que principe actif, un mélange d'α-glucanes ramifiés possédant les caractéristiques (A) à (C) : (A) ayant du glucose comme composant saccharidique ; (B) possédant une structure ramifiée présentant un degré de polymérisation du glucose de 1 ou plus, ladite structure ramifiée étant liée, par l'intermédiaire d'une liaison autre qu'une liaison α-1,4, au résidu glucose final non réducteur positionné à une extrémité d'un glucane linéaire présentant un degré de polymérisation du glucose de 3 ou plus et au sein duquel les molécules de glucose sont liées les unes aux autres par l'intermédiaire de liaisons α-1,4 ; et (C) formant de l'isomaltose lorsque digérés par une isomaltodextranase.
(JA)
【課題】 本発明は、日常の食生活で継続的に経口摂取可能であり、副作用の心配のない、免疫調節剤及びその用途を提供することを課題とする。 【解決手段】 下記(A)乃至(C)の特徴を有する分岐α-グルカン混合物を有効成分として含有する免疫調節剤を提供することによって上記課題を解決する: (A)グルコースを構成糖とし、 (B)α-1,4結合を介して連結したグルコース重合度3以上の直鎖状グルカンの一端に位置する非還元末端グルコース残基にα-1,4結合以外の結合を介して連結したグルコース重合度1以上の分岐構造を有し、 (C)イソマルトデキストラナーゼ消化により、イソマルトースを生成する。
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Latest bibliographic data on file with the International Bureau