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1. WO2016135119 - METHOD FOR THE DIAGNOSIS OF ENDOMETRIAL CARCINOMA

Publication Number WO/2016/135119
Publication Date 01.09.2016
International Application No. PCT/EP2016/053726
International Filing Date 23.02.2016
IPC
G01N 33/574 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
574for cancer
G06F 19/00 2011.01
GPHYSICS
06COMPUTING; CALCULATING OR COUNTING
FELECTRIC DIGITAL DATA PROCESSING
19Digital computing or data processing equipment or methods, specially adapted for specific applications
CPC
G01N 33/57442
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
574for cancer
57407Specifically defined cancers
57442of the uterus and endometrial
Applicants
  • HOSMOTIC SRL [IT]/[IT]
Inventors
  • TROISI, Jacopo
  • SCALA, Giovanni
  • CAMPIGLIA, Pietro
  • ZULLO, Fulvio
  • GUIDA, Maurizio
Agents
  • LONGONI, Alessandra
Priority Data
10201500000715127.02.2015IT
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD FOR THE DIAGNOSIS OF ENDOMETRIAL CARCINOMA
(FR) MÉTHODE POUR LE DIAGNOSTIC DU CARCINOME DE L'ENDOMÈTRE
Abstract
(EN)
A method for the diagnosis of the endometrial carcinoma based on metabolomic analysis of blood is disclosed, comprising the following steps: (I) a training phase comprising: - GC-MS or GCxGCMS analysis of blood samples derived from patients with endometrial carcinoma and healthy controls; - integration of the obtained results by a multivariate analysis using at least a discriminant analysis model or a model of computer learning to train at least a classification model; (II) an assignment phase comprising GC-MS or GCxGCMS analysis of an unknown blood sample and its assignment to a class on the base of the classification model formulated in the training phase (I).
(FR)
L'invention concerne une méthode pour le diagnostic du carcinome de l'endomètre basé sur une analyse métabolomique du sang, comprenant les étapes suivantes : (I) - phase d'apprentissage comprenant : l'analyse par GC-MS ou GCxGCMS d'échantillons de sang issus de patientes atteintes de carcinome de l'endomètre et de témoins sains ; - l'intégration des résultats obtenus par une analyse multivariée utilisant au moins un modèle d'analyse discriminante ou un modèle d'apprentissage assisté par ordinateur pour générer au moins un modèle de classification ; (II) - phase d'affectation comprenant une analyse par GC-MS ou GCxGCMS d'un échantillon de sang inconnu et son affectation à une classe sur la base du modèle de classification formulé lors de la phase d'apprentissage (I).
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