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1. (WO2016135119) METHOD FOR THE DIAGNOSIS OF ENDOMETRIAL CARCINOMA
Latest bibliographic data on file with the International Bureau
Pub. No.: WO/2016/135119 International Application No.: PCT/EP2016/053726
Publication Date: 01.09.2016 International Filing Date: 23.02.2016
IPC:
G01N 33/574 (2006.01) ,G06F 19/00 (2011.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
574
for cancer
G PHYSICS
06
COMPUTING; CALCULATING; COUNTING
F
ELECTRIC DIGITAL DATA PROCESSING
19
Digital computing or data processing equipment or methods, specially adapted for specific applications
Applicants:
HOSMOTIC SRL [IT/IT]; Via Raffaele Bosco 178 80069 Vico Equense (NA), IT
Inventors:
TROISI, Jacopo; IT
SCALA, Giovanni; IT
CAMPIGLIA, Pietro; IT
ZULLO, Fulvio; IT
GUIDA, Maurizio; IT
Agent:
LONGONI, Alessandra; IT
Priority Data:
10201500000715127.02.2015IT
Title (EN) METHOD FOR THE DIAGNOSIS OF ENDOMETRIAL CARCINOMA
(FR) MÉTHODE POUR LE DIAGNOSTIC DU CARCINOME DE L'ENDOMÈTRE
Abstract:
(EN) A method for the diagnosis of the endometrial carcinoma based on metabolomic analysis of blood is disclosed, comprising the following steps: (I) a training phase comprising: - GC-MS or GCxGCMS analysis of blood samples derived from patients with endometrial carcinoma and healthy controls; - integration of the obtained results by a multivariate analysis using at least a discriminant analysis model or a model of computer learning to train at least a classification model; (II) an assignment phase comprising GC-MS or GCxGCMS analysis of an unknown blood sample and its assignment to a class on the base of the classification model formulated in the training phase (I).
(FR) L'invention concerne une méthode pour le diagnostic du carcinome de l'endomètre basé sur une analyse métabolomique du sang, comprenant les étapes suivantes : (I) - phase d'apprentissage comprenant : l'analyse par GC-MS ou GCxGCMS d'échantillons de sang issus de patientes atteintes de carcinome de l'endomètre et de témoins sains ; - l'intégration des résultats obtenus par une analyse multivariée utilisant au moins un modèle d'analyse discriminante ou un modèle d'apprentissage assisté par ordinateur pour générer au moins un modèle de classification ; (II) - phase d'affectation comprenant une analyse par GC-MS ou GCxGCMS d'un échantillon de sang inconnu et son affectation à une classe sur la base du modèle de classification formulé lors de la phase d'apprentissage (I).
 front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP3262416US20180038867JP2018511811ES2711814