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1. WO2016134854 - METHODS FOR THE PREPARATION OF TOPIROXOSTAT AND INTERMEDIATES THEREOF

Publication Number WO/2016/134854
Publication Date 01.09.2016
International Application No. PCT/EP2016/000343
International Filing Date 24.02.2016
IPC
C07D 401/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
A61K 31/4439 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
4427containing further heterocyclic ring systems
4439containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A61P 13/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
CPC
A61P 13/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
C07D 401/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
Applicants
  • PHARMATHEN S.A. [GR]/[GR]
Inventors
  • KOFTIS V. Theocharis
  • NEOKOSMIDIS, Efstratios
  • ANDREOU, Thanos
  • STATHAKIS, Christos
  • GKIZIS L., Petros
Agents
  • BROWN, Andrew Stephen
Priority Data
PCT/EP2015/00043025.02.2015EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS FOR THE PREPARATION OF TOPIROXOSTAT AND INTERMEDIATES THEREOF
(FR) PROCÉDÉ DE PRÉPARATION DE TOPIROXOSTAT ET LEURS INTERMÉDIAIRES
Abstract
(EN)
The present invention relates to novel preparation methods for Topiroxostat through novel intermediates comprising novel methods for the formation of the triazole ring and for the cyanation of the pyridyl ring.
(FR)
La présente invention concerne de nouveaux procédés de préparation de Topiroxostat par le biais de nouveaux intermédiaires comprenant de nouveaux procédés pour la formation du cycle triazole et pour la cyanation du cycle pyridyle.
Latest bibliographic data on file with the International Bureau