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1. (WO2016120530) A CARBOXAMIDE DERIVATIVE AND ITS DIASTEREOMERS IN STABLE CRYSTALLINE FORM
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2016/120530 International Application No.: PCT/FI2016/050054
Publication Date: 04.08.2016 International Filing Date: 28.01.2016
IPC:
C07D 231/14 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
231
Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
02
not condensed with other rings
10
having two or three double bonds between ring members or between ring members and non-ring members
14
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Applicants:
ORION CORPORATION [FI/FI]; Orionintie 1 FI-02200 Espoo, FI
Inventors:
TÖRMÄKANGAS, Olli; FI
HEIKKINEN, Terhi; FI
Agent:
ORION CORPORATION/INTELLECTUAL PROPERTY RIGHTS; P.O. Box 65 FI-02101 Espoo, FI
Priority Data:
2015003330.01.2015FI
Title (EN) A CARBOXAMIDE DERIVATIVE AND ITS DIASTEREOMERS IN STABLE CRYSTALLINE FORM
(FR) DÉRIVÉ DE CARBOXAMIDE ET SES DIASTÉRÉOMÈRES SOUS UNE FORME CRISTALLINE STABLE
Abstract:
(EN) The present disclosure relates to solid crystalline forms of N-((S)-1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-5-(1-hydroxyethyl)-1H-pyrazole-3- carboxamide (I) and the diastereomers thereof, and to methods for preparing such crystalline forms. Compound (I)and the diastereomers thereof are potent androgen receptor (AR) modulators useful as a medicament.
(FR) La présente divulgation concerne des formes cristallines solides de N-((S)-1-(3-(3-chloro-4-cyanophényl)-1H-pyrazol-1-yl)-propan-2-yl)-5- (1-hydroxyéthyl)-1H-pyrazole-3-carboxamide (I) et ses diastéréomères, et des procédés de préparation desdites formes cristallines. Le composé (I) et ses diastéréomères sont de puissants modulateurs des récepteurs d'androgènes (AR) utiles à titre de médicament.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP3250554US20180008577JP2018503662