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1. WO2016116175 - CALIXPYRROLE COMPOUNDS AND CREATININE-SELECTIVE ELECTRODES COMPRISING THEM

Publication Number WO/2016/116175
Publication Date 28.07.2016
International Application No. PCT/EP2015/067241
International Filing Date 28.07.2015
IPC
C07D 403/14 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
14containing three or more hetero rings
C07D 487/22 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
22in which the condensed system contains four or more hetero rings
G01N 27/333 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
27Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means
26by investigating electrochemical variables; by using electrolysis or electrophoresis
28Electrolytic cell components
30Electrodes, e.g. test electrodes; Half-cells
333Ion-selective electrodes or membranes
CPC
B01J 39/16
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
39Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
08Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
16Organic material
C07D 403/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
14containing three or more hetero rings
C07D 487/22
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
22in which the condensed system contains four or more hetero rings
C07D 491/22
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
491Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
22in which the condensed system contains four or more hetero rings
C07F 9/657181
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
6564having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
6571having phosphorus and oxygen atoms as the only ring hetero atoms
657163the ring phosphorus atom being bound to at least one carbon atom
657181the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
C08J 2327/06
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G
2327Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Derivatives of such polymers
02not modified by chemical after-treatment
04containing chlorine atoms
06Homopolymers or copolymers of vinyl chloride
Applicants
  • FUNDACIÓ INSTITUT CATALÀ D'INVESTIGACIÓ QUÍMICA (ICIQ) [ES]/[ES]
  • INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS [ES]/[ES]
  • UNIVERSITAT ROVIRA I VIRGILI [ES]/[ES]
Inventors
  • ADRIAENSSENS, Louis
  • BALLESTER, Pau
  • ANDRADE, Francisco Javier
  • BLONDEAU, Pascal
  • RIUS, Francesc Xavier
  • GUINOVART PAVÓN, Tomás De Aquino
  • HERNÁNDEZ ALONSO, Daniel
Agents
  • ZBM PATENTS - ZEA, BARLOCCI & MARKVARDSEN
Priority Data
15382007.119.01.2015EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) CALIXPYRROLE COMPOUNDS AND CREATININE-SELECTIVE ELECTRODES COMPRISING THEM
(FR) COMPOSÉS CALIXPYRROLE ET ÉLECTRODES SÉLECTIVES DE CRÉATININE LES COMPRENANT
Abstract
(EN) These compounds are of formula (la), (lb), (Ic), or are stereoisomers thereof, wherein: R1 is hydrogen, (C1-C20)alkyl; (C3-C20)alkenyl; (C3-C20)alkynyl; (C1- C6)alkyl-O-; (C3-C20)cycloalkyl; (C1-C20)haloalkyl; (C6-C20)aryl optionally substituted; (C6-C20)heteroaryl optionally substituted;; R2 and R2' are hydrogen; (C1-C20)alkyl; (C1-C6)alkyl-O-; (C1-C6)haloalkyl; halogen;cyano; and nitro; to Z1 to Z4 are diradicals of formula (III) wherein A1 and A2 are -O- or -NR3-, wherein R3 is selected from the group consisting of hydrogen and (C1- C20)alkyl; and G is (C1-C6)alkyl;;-P(=S)R5-; -P(=O)R4; -P(=O)(OR4)-; - P(=O)(NR6R7)-; -S(=O)2-; -S(=O)-; or -C(=O)-; and Y1 to Y4 are (C1-C8)alkyl; (C3-C7)cycloalkyl; (C6-C20)aryl optionally substituted; or (C6-C20)heteroaryl optionally substituted; and FG1 and FG2 are H, OH, or NHR8. These compounds are useful as ionophores for creatinine quantification.
(FR) La présente invention concerne des composés de formule (Ia), (Ib), (Ic), ou leurs stéréoisomères, : R1 étant un atome d'hydrogène, un groupe alkyle en (C1 à C20); alcényle en (C3 à C20); alcynyle en (C3 à C20); (alkyle en (C1 à C6))-O-; cycloalkyle en (C3 à C20); halogénoalkyle en (C1 à C20); aryle en (C6 à C20) éventuellement substitué; hétéroaryle en (C6 à C20) éventuellement substitué; R2 et R2' sont un atome d'hydrogène; un groupe alkyle en (C1 à C20); (alkyle en (C1 à C6))-O-; halogénoalkyle en (C1 à C6); halogéno; cyano; et nitro; Z1 à Z4 sont des biradicaux de formule (III) où A1 et A2 sont -O- ou -NR3-, où R3 est sélectionné dans le groupe constitué d'un atome d'hydrogène et d'un groupe alkyle en (C1 à C20); et G est un groupe alkyle en (C1 à C6); -P(=S)R5-; -P(=O)R4; -P(=O)(OR4)-; -P(=O)(NR6R7)-; -S(=O)2-; -S(=O)-; ou -C(=O)-; et Y1 à Y4 sont un groupe alkyle en (C1 à C8); cycloalkyle en (C3 à C7); aryle en (C6 à C20) éventuellement substitué; ou hétéroaryle en (C6 à C20) éventuellement substitué; et FG1 et FG2 sont un atome H, un groupe OH, ou NHR8. Ces composés sont utiles comme ionophores pour la quantification de la créatinine.
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