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1. WO2016110708 - PROCESS

Publication Number WO/2016/110708
Publication Date 14.07.2016
International Application No. PCT/GB2016/050035
International Filing Date 08.01.2016
IPC
C12P 7/52 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7Preparation of oxygen-containing organic compounds
40containing a carboxyl group
52Propionic acid; Butyric acids
C12P 41/00 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
41Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
CPC
C12P 41/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
41Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
C12P 7/52
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7Preparation of oxygen-containing organic compounds
40containing a carboxyl group ; including Peroxycarboxylic acids
52Propionic acid; Butyric acids
Applicants
  • AESICA PHARMACEUTICALS LIMITED [GB]/[GB]
Inventors
  • RHODES, Barrie
  • MOSELEY, Jonathan
  • WELLS, Andrew
Agents
  • GILHOLM, Stephen Philip
Priority Data
1500277.708.01.2015GB
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) PROCESS
(FR) PROCÉDÉ
Abstract
(EN) There is described a process for the preparation of a stereospecific form of flurbiprofen, or a pharmaceutically acceptable salt thereof, which comprises subjecting a flurbiprofen ester, comprising a mixture (R)-(-)-flurbiprofen and (S)-(+)-flurbiprofen, to the action of an biocatalyst capable of stereo selective de-esterification of the ester; provided that the biocatalyst is not Aspergillus oryzae; Bacillus cereus C71; Candida Antarctica lipase B (Novozym ® 435); Candida cylindracea; Candida rugosa lipase; Carica papaya lipase; Pseudomonas sp. KCTC 10122BP and Serratia marcescens ES-2.
(FR) L'invention concerne un procédé pour la préparation d'une forme stéréospécifique du flurbiprofène, ou d'un sel pharmaceutiquement acceptable de celui-ci, le procédé consistant à soumettre un ester de flurbiprofène, comprenant un mélange de (R)-(-)-flurbiprofène et de (S)-(+)-flurbiprofène, à l'action d'un biocatalyseur capable d'effectuer une désestérification stéréosélective de l'ester ; à condition que le biocatalyseur ne soit pas Aspergillus oryzae ; Bacillus cereus C71 ; une lipase B de Candida Antarctica (Novozyme® 435) ; Candida cylindracea; une lipase de Candida rugosa ; une lipase de Carica Papaya ; Pseudomonas sp.KCTC 10122 BP et Serratia marcescens ES-2.
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