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152. (WO2016110708) PROCESS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2016/110708 International Application No.: PCT/GB2016/050035
Publication Date: 14.07.2016 International Filing Date: 08.01.2016
IPC:
C12P 7/52 (2006.01) ,C12P 41/00 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7
Preparation of oxygen-containing organic compounds
40
containing a carboxyl group
52
Propionic acid; Butyric acids
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
41
Processes using enzymes or micro-organisms to separate optical isomers from a racemic mixture
Applicants:
AESICA PHARMACEUTICALS LIMITED [GB/GB]; Q5 Quorum Business Park Benton Lane Newcastle upon Tyne NE12 8BS, GB
Inventors:
RHODES, Barrie; GB
MOSELEY, Jonathan; GB
WELLS, Andrew; GB
Agent:
GILHOLM, Stephen Philip; GB
Priority Data:
1500277.708.01.2015GB
Title (EN) PROCESS
(FR) PROCÉDÉ
Abstract:
(EN) There is described a process for the preparation of a stereospecific form of flurbiprofen, or a pharmaceutically acceptable salt thereof, which comprises subjecting a flurbiprofen ester, comprising a mixture (R)-(-)-flurbiprofen and (S)-(+)-flurbiprofen, to the action of an biocatalyst capable of stereo selective de-esterification of the ester; provided that the biocatalyst is not Aspergillus oryzae; Bacillus cereus C71; Candida Antarctica lipase B (Novozym ® 435); Candida cylindracea; Candida rugosa lipase; Carica papaya lipase; Pseudomonas sp. KCTC 10122BP and Serratia marcescens ES-2.
(FR) L'invention concerne un procédé pour la préparation d'une forme stéréospécifique du flurbiprofène, ou d'un sel pharmaceutiquement acceptable de celui-ci, le procédé consistant à soumettre un ester de flurbiprofène, comprenant un mélange de (R)-(-)-flurbiprofène et de (S)-(+)-flurbiprofène, à l'action d'un biocatalyseur capable d'effectuer une désestérification stéréosélective de l'ester ; à condition que le biocatalyseur ne soit pas Aspergillus oryzae ; Bacillus cereus C71 ; une lipase B de Candida Antarctica (Novozyme® 435) ; Candida cylindracea; une lipase de Candida rugosa ; une lipase de Carica Papaya ; Pseudomonas sp.KCTC 10122 BP et Serratia marcescens ES-2.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)