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152. (WO2016110708) PROCESS

Pub. No.:    WO/2016/110708    International Application No.:    PCT/GB2016/050035
Publication Date: Fri Jul 15 01:59:59 CEST 2016 International Filing Date: Sat Jan 09 00:59:59 CET 2016
IPC: C12P 7/52
C12P 41/00
Applicants: AESICA PHARMACEUTICALS LIMITED
Inventors: RHODES, Barrie
MOSELEY, Jonathan
WELLS, Andrew
Title: PROCESS
Abstract:
There is described a process for the preparation of a stereospecific form of flurbiprofen, or a pharmaceutically acceptable salt thereof, which comprises subjecting a flurbiprofen ester, comprising a mixture (R)-(-)-flurbiprofen and (S)-(+)-flurbiprofen, to the action of an biocatalyst capable of stereo selective de-esterification of the ester; provided that the biocatalyst is not Aspergillus oryzae; Bacillus cereus C71; Candida Antarctica lipase B (Novozym ® 435); Candida cylindracea; Candida rugosa lipase; Carica papaya lipase; Pseudomonas sp. KCTC 10122BP and Serratia marcescens ES-2.