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1. (WO2016106400) RNA INTERFERENCE AGENTS FOR GST-PI GENE MODULATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/106400    International Application No.:    PCT/US2015/067553
Publication Date: 30.06.2016 International Filing Date: 28.12.2015
IPC:
A61K 31/713 (2006.01), A61K 31/52 (2006.01)
Applicants: NITTO DENKO CORPORATION [JP/JP]; 1-2, Shimohozumi 1-chome, Ibaraki-shi, Osaka 567-8680 (JP).
YING, Wenbin [US/US]; (US) (US only)
Inventors: YING, Wenbin; (US).
MINOMI, Kenjirou; (JP).
HARBORTH, Jens; (US).
TAKAHASHI, Hirokazu; (JP).
TERADA, Erika; (JP).
ZHANG, Jun; (US).
AHMADIAN, Mohammad; (US)
Agent: ECKMAN, Richard, R.; (US)
Priority Data:
2014-266198 26.12.2014 JP
62/184,239 24.06.2015 US
62/266,664 13.12.2015 US
Title (EN) RNA INTERFERENCE AGENTS FOR GST-PI GENE MODULATION
(FR) AGENTS D'INTERFÉRENCE ARN POUR LA MODULATION DU GÈNE GST-PI
Abstract: front page image
(EN)This invention provides compounds, compositions and methods for modulating the expression of human GST-pi using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. Provided are a range of siRNA structures, having one or more of nucleotides being modified or chemically-modified. Advantageous structures include siRNAs with 2'-deoxy nucleotides located in the seed region, as well as other nucleotide modifications
(FR)La présente invention concerne des composés, des compositions et des procédés de modulation de l'expression de GST-pi humain au moyen de l'interférence ARN. Les molécules d'interférence ARN peuvent être utilisées dans des procédés de prévention ou de traitement de maladies, par exemple des tumeurs malignes. L'invention concerne une gamme de structures d'ARNsi, ayant un ou plusieurs nucléotides étant modifiés ou chimiquement modifiés. Des structures comprennent des ARNsi avec des 2'-désoxynucléotides situés dans la région seed, ainsi que d'autres modifications de nucléotides.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)