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1. (WO2016106244) CRISPR HAVING OR ASSOCIATED WITH DESTABILIZATION DOMAINS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/106244    International Application No.:    PCT/US2015/067177
Publication Date: 30.06.2016 International Filing Date: 21.12.2015
IPC:
C12N 15/10 (2006.01), C12N 9/22 (2006.01)
Applicants: THE BROAD INSTITUTE INC. [US/US]; 415 Main Street Cambridge, MA 02142 (US).
MASSACHUSETTS INSTITUTE OF TECHNOLOGY [US/US]; 77 Massachusetts Ave. Cambridge, MA 02142 (US).
PRESIDENT AND FELLOWS OF HARVARD COLLEGE [--/US]; 17 Quincy Street Cambridge, MA 02142 (US)
Inventors: ZHANG, Feng; (US).
ZETSCHE, Bernd; (US).
CHOUDHARY, Amit; (US)
Agent: KOWALSKI, Thomas, J.; (US)
Priority Data:
62/181,151 17.06.2015 US
62/096,656 24.12.2014 US
Title (EN) CRISPR HAVING OR ASSOCIATED WITH DESTABILIZATION DOMAINS
(FR) CRISPR PRÉSENTANT OU ASSOCIÉ AVEC UN DOMAINE DE DÉSTABILISATION
Abstract: front page image
(EN)The disclosure includes non-naturally occurring or engineered CRISPR Cas9, each associated with at least one destabilization domain (DD), along with compositions, systems and complexes involving the DD-CRISPR Cas9, nucleic acid molecules and vectors encoding the same, delivery systems involving the same, uses therefor.
(FR)L'invention concerne des CRISPR Cas9, d'origine non naturelle ou obtenus par génie génétique, associés chacun à au moins un domaine de déstabilisation (DD), ainsi que des compositions, des systèmes et des complexes impliquant le DD-CRISPR Cas9, des molécules d'acide nucléique et des vecteurs codant pour ces dernières, des systèmes d'administration faisant appel à ces dernières et leurs utilisations.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)