WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2016106221) ANTI-MERTK AGONISTIC ANTIBODIES AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/106221    International Application No.:    PCT/US2015/067118
Publication Date: 30.06.2016 International Filing Date: 21.12.2015
IPC:
C07K 16/28 (2006.01), C07K 14/705 (2006.01), A61K 39/395 (2006.01)
Applicants: THE ROCKEFELLER UNIVERSITY [US/US]; 1230 York Avenue New York, NY 10065 (US)
Inventors: TAVAZOIE, Sohail; (US).
HALBERG, Nils; (US).
TAVAZOIE, Masoud; (US)
Agent: NORTON, Gerard, P.; (US)
Priority Data:
62/095,325 22.12.2014 US
Title (EN) ANTI-MERTK AGONISTIC ANTIBODIES AND USES THEREOF
(FR) ANTICORPS AGONISTES ANTI-MERTK ET LEURS UTILISATIONS
Abstract: front page image
(EN)The present disclosure provides antibodies that specifically bind to Mer Tyrosine Kinase (MERTK) (e.g., human MERTK, or both human and mouse MERTK) and compositions comprising such antibodies, wherein said antibody agonizes MERTK signaling on endothelial cells. The present disclosure also provides methods for treating cancer, by administering an antibody that specifically binds to MERTK and agonizes MERTK signaling on endothelial cells.
(FR)La présente invention concerne des anticorps qui se lient spécifiquement à la tyrosine kinase Mer (MERTK) (par exemple, MERTK humaine, ou MERTK humaine et murine) et des compositions comprenant de tels anticorps, ledit anticorps étant un agoniste de la signalisation MERTK sur les cellules endothéliales. La présente invention concerne également des procédés pour traiter le cancer, par administration d'un anticorps qui se lie spécifiquement à MERTK et qui est un agoniste de la signalisation MERTK sur les cellules endothéliales.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)