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1. (WO2016106157) BISPECIFIC TETRAVALENT ANTIBODIES AND METHODS OF MAKIING AND USING THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/106157    International Application No.:    PCT/US2015/066951
Publication Date: 30.06.2016 International Filing Date: 19.12.2015
IPC:
A61K 39/395 (2006.01)
Applicants: SYSTIMMUNE, INC. [US/US]; 2023 120th Ave. NE Bellevue, Washington 98005 (US)
Inventors: GAO, Zeren; (US).
TAN, Phil; (US).
KOVACEVICH, Brian; (US).
RENSHAW, Blair; (US).
ADAMO, Jeffrey; (US).
MAK, Nga Sze Amanda; (US).
ZHUO, Shi; (CN).
CHEN, Lan; (CN)
Agent: TIAN, Le; (US)
Priority Data:
62/095,348 22.12.2014 US
Title (EN) BISPECIFIC TETRAVALENT ANTIBODIES AND METHODS OF MAKIING AND USING THEREOF
(FR) ANTICORPS TÉTRAVALENTS BISPÉCIFIQUES ET LEURS PROCÉDÉS DE FABRICATION ET D'UTILISATION
Abstract: front page image
(EN)A bispecific tetravalent antibody comprising an IgG having a pair of heavy chains and a pair of light chains, and two scFv components being connected to either C or N terminals of the heavy or light chains. The bispecific tetravalent antibody may have a binding specificity for two different members of EGFR family.
(FR)Un anticorps tétravalent bispécifique comprenant une IgG possédant une paire de chaînes lourdes et une paire de chaînes légères, et deux composants scFv reliés à l'une ou l'autre de l'extrémité C ou N terminale des chaînes lourdes ou légères. L'anticorps tétravalent bispécifique peut présenter une spécificité de liaison pour deux membres différents de la famille EGFR.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)