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1. (WO2016105477) DERIVATIVES OF 5-PHENYL- OR 5-HETEROARYLTHIAZOL-2-CARBOXYLIC AMIDE USEFUL FOR THE TREATMENT OF INTER ALIA CYSTIC FIBROSIS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/105477    International Application No.:    PCT/US2015/000202
Publication Date: 30.06.2016 International Filing Date: 23.12.2015
IPC:
C07D 277/56 (2006.01), C07D 417/12 (2006.01), A61K 31/341 (2006.01), A61K 31/4155 (2006.01), A61K 31/4178 (2006.01), A61K 31/4192 (2006.01), A61K 31/4245 (2006.01), A61K 31/425 (2006.01), A61K 31/433 (2006.01), A61P 11/00 (2006.01), A61P 37/00 (2006.01)
Applicants: PROTEOSTASIS THERAPEUTICS, INC [US/US]; 200 Technology Square, 4th Floor Cambridge, MA 02139 (US)
Inventors: BASTOS, Cecilia, M.; (US).
MUNOZ, Benito; (US).
TAIT, Bradley; (US)
Agent: KAVANAUGH, Theresa, C.; (US)
Priority Data:
62/102,208 12.01.2015 US
62/096,416 23.12.2014 US
Title (EN) DERIVATIVES OF 5-PHENYL- OR 5-HETEROARYLTHIAZOL-2-CARBOXYLIC AMIDE USEFUL FOR THE TREATMENT OF INTER ALIA CYSTIC FIBROSIS
(FR) DÉRIVÉS D'AMIDES 5-PHÉNYL- OU 5-HÉTÉROARYLTHIAZOL-2-CARBOXYLIQUES SERVANT AU TRAITEMENT, ENTRE AUTRES, DE LA FIBROSE CYSTIQUE
Abstract: front page image
(EN)The present disclosure is based, in part, on the discovery that disclosed compounds such as those having Formula (IlIa), (III), or (IV) can increase cystic fibrosis transmembrane conductance regulator (CFTR) activity as measured in human bronchial epithelial (hBE) cells.
(FR)La présente invention est basée, en partie, sur le fait que les composés selon l'invention, tels que ceux ayant la formule (IIIa), (III), ou (IV) peuvent augmenter l'activité du régulateur de la conductance transmembranaire de la fibrose cystique (CFTR) telle que mesurée dans des cellules épithéliales bronchiques humaines (hBE).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)