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1. (WO2016105468) DERIVATIVES OF 3-HETEROARYLISOXAZOL-5-CARBOXYLIC AMIDE USEFUL FOR THE TREATMENT OF INTER ALIA CYSTIC FIBROSIS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/105468    International Application No.:    PCT/US2015/000189
Publication Date: 30.06.2016 International Filing Date: 23.12.2015
IPC:
C07D 413/12 (2006.01), C07D 417/12 (2006.01), A61K 31/4155 (2006.01), A61K 31/4192 (2006.01), A61K 31/42 (2006.01), A61K 31/4245 (2006.01), A61K 31/433 (2006.01), A61P 11/00 (2006.01), A61P 37/00 (2006.01)
Applicants: PROTEOSTASIS THERAPEUTICS, INC. [US/US]; 200 Technology Square, 4th Floor Cambridge, MA 02139 (US)
Inventors: BASTOS, Cecilia, M.; (US).
MUNOZ, Benito; (US).
TAIT, Bradley; (US)
Agent: KAVANAUGH, Theresa, C.; (US)
Priority Data:
62/096,368 23.12.2014 US
62/102,203 12.01.2015 US
Title (EN) DERIVATIVES OF 3-HETEROARYLISOXAZOL-5-CARBOXYLIC AMIDE USEFUL FOR THE TREATMENT OF INTER ALIA CYSTIC FIBROSIS
(FR) DÉRIVÉS DE 3-HÉTÉROARYLISOXAZOL-5-AMIDE CARBOXYLIQUE UTILES DANS LE TRAITEMENT, ENTRE AUTRES, D'UNE FIBROSE KYSTIQUE
Abstract: front page image
(EN)The present disclosure is based, in part, on the discovery that disclosed compounds can increase cystic fibrosis transmembrane conductance regulator (CFTR) activity as measured in human bronchial epithelial (hBE) cells.
(FR)La présente invention repose, en partie, sur la découverte selon laquelle des composés de l'invention peuvent augmenter l'activité du régulateur de la conductance transmembranaire de la fibrose kystique (CFTR) telle que mesurée dans des cellules épithéliales bronchiques humaines (hBE).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)