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1. (WO2016104617) QUINOLINE DERIVATIVE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/104617    International Application No.:    PCT/JP2015/086050
Publication Date: 30.06.2016 International Filing Date: 24.12.2015
IPC:
C07D 401/14 (2006.01), A61K 31/4709 (2006.01), A61K 31/517 (2006.01), A61K 31/55 (2006.01), A61P 7/02 (2006.01), A61P 9/00 (2006.01), A61P 9/10 (2006.01), A61P 13/12 (2006.01), A61P 17/06 (2006.01), A61P 19/02 (2006.01), A61P 29/00 (2006.01), A61P 35/00 (2006.01), A61P 35/02 (2006.01), A61P 35/04 (2006.01), A61P 43/00 (2006.01), C07D 471/04 (2006.01)
Applicants: ONO PHARMACEUTICAL CO., LTD. [JP/JP]; 1-5, Doshomachi 2-chome, Chuo-ku, Osaka-shi, Osaka 5418526 (JP)
Inventors: INUKAI, Takayuki; (JP).
TAKEUCHI, Jun; (JP).
YASUHIRO, Tomoko; (JP)
Agent: AOKI, Atsushi; (JP)
Priority Data:
2014-262146 25.12.2014 JP
Title (EN) QUINOLINE DERIVATIVE
(FR) DÉRIVÉ DE QUINOLÉINE
(JA) キノリン誘導体
Abstract: front page image
(EN)This compound represented by general formula (I) and having a quinoline skeleton has a strong Axl inhibitory activity. Consequently, this compound can be a therapeutic agent for Axl-related diseases, for example, cancers such as acute myeloid leukemia, chronic myeloid leukemia, melanoma, breast cancer, pancreatic cancer and glioma, kidney diseases, immune system diseases and cardiovascular diseases.
(FR)Ce composé représenté par la formule générale (I) et ayant un squelette de quinoléine a une forte activité inhibitrice d'Axl. Par conséquent, ce composé peut être un agent thérapeutique pour des maladies associées à l'Axl, par exemple, des cancers tels que la leucémie myéloïde aiguë, la leucémie myéloïde chronique, le mélanome, le cancer du sein, le cancer du pancréas et le gliome, les maladies rénales, des maladies du système immunitaire et des maladies cardio-vasculaires.
(JA) 一般式(I)で示されるキノリン骨格を有する化合物は、強力なAxl阻害活性を有することから、Axl関連疾患、例えば、急性骨髄性白血病、慢性骨髄性白血病、メラノーマ、乳癌、膵臓癌、神経膠腫等の癌、腎臓疾患、免疫系疾患、循環器系疾患の治療剤となり得る。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)