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1. (WO2016102965) CELL
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/102965    International Application No.:    PCT/GB2015/054137
Publication Date: 30.06.2016 International Filing Date: 23.12.2015
C07K 14/705 (2006.01), C07K 16/28 (2006.01), C07K 16/30 (2006.01), C12N 5/0783 (2010.01)
Applicants: UCL BUSINESS PLC [GB/GB]; The Network Building 97 Tottenham Court Road London W1T 4TP (GB).
AUTOLUS LTD [GB/GB]; Forest House Depot Road London W12 7RP (GB)
Inventors: PULÉ, Martin; (GB).
CORDOBA, Shaun; (GB).
ONUOHA, Shimobi; (GB).
THOMAS, Simon; (GB)
Agent: WILLIAMS, Aylsa; (GB)
Priority Data:
1423172.4 24.12.2014 GB
Title (EN) CELL
Abstract: front page image
(EN)The present invention provides a cell which co-expresses a first chimeric antigen receptor (CAR) and second CAR at the cell surface, each CAR comprising an antigen-binding domain, wherein the antigen-binding domain of the first CAR binds to CD19 and the antigen- binding domain of the second CAR binds to CD22.
(FR)La présente invention concerne une cellule qui co-exprime un premier récepteur d'antigène chimère (CAR) et un second CAR à la surface de la cellule, chaque CAR comprenant un domaine de liaison à l'antigène, le domaine de liaison à l'antigène du premier CAR se liant à CD19 et le domaine de liaison à l'antigène du second CAR se liant à CD22.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)