WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2016101412) CRYSTALLIZATION WATER-FREE CALCIUM DIBUTYRYLADENOSINE CYCLOPHOSPHATE CRYSTAL FORM, AND PREPARATION METHOD AND USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/101412    International Application No.:    PCT/CN2015/073668
Publication Date: 30.06.2016 International Filing Date: 05.03.2015
IPC:
C07H 19/213 (2006.01), C07H 1/06 (2006.01), A61K 31/7076 (2006.01), A61P 9/00 (2006.01)
Applicants: SPH NO.1 BIOCHEMICAL & PHARMACEUTICAL CO., LTD. [CN/CN]; No. 1317 Jianchuan Road, Minhang District Shanghai 200240 (CN).
SHANGHAI ZIYUAN PHARMACEUTICAL CO., LTD. [CN/CN]; No.749 Guanghua Road, Minhang District Shanghai 201108 (CN)
Inventors: HUANG, Zhenhui; (CN).
YANG, Liuqing; (CN).
HUO, Jianli; (CN).
ZHU, Xinlei; (CN).
DING, Jinguo; (CN).
ZHANG, Zhigang; (CN)
Agent: SHANGHAI BESHINING LAW OFFICE; 21st Floor, SFECO Mansion, No.681 Xiaomuqiao Road Shanghai 200032 (CN)
Priority Data:
201410840112.8 24.12.2014 CN
Title (EN) CRYSTALLIZATION WATER-FREE CALCIUM DIBUTYRYLADENOSINE CYCLOPHOSPHATE CRYSTAL FORM, AND PREPARATION METHOD AND USE THEREOF
(FR) FORME CRISTALLINE DE DIBUTYRYLADÉNOSINE CYCLOPHOSPHATE DE CALCIUM SANS EAU DE CRISTALLISATION, ET PROCÉDÉ DE PRÉPARATION ET UTILISATION DE CELLE-CI
(ZH) 一种无结晶水二丁酰环磷腺苷钙晶型及其制备方法和应用
Abstract: front page image
(EN)Disclosed are a crystallization water-free calcium dibutyryladenosine cyclophosphate crystal form, and a preparation method and a use thereof. In an X-ray powder diffraction pattern using Cu-Kα as a source of radiation, the crystallization water-free calcium dibutyryladenosine cyclophosphate crystal form has characteristic peaks at positions where diffraction angles 2θ are equal to 12.3°±0.2°, 17.6°±0.2°, 21.4°±0.2°, 24.7°±0.2°, 25.3°±0.2° and 27.8°±0.2°. The crystallization water-free calcium dibutyryladenosine cyclophosphate crystal form of the present invention has a high purity, and good stability; the preparation method is simple and convenient, has good reproducibility, and is easy to industrially popularize and apply.
(FR)La présente invention concerne une forme cristalline de dibutyryladénosine cyclophosphate de calcium sans eau de cristallisation, et un procédé de préparation et une utilisation de celle-ci. Dans un diagramme de diffraction des rayons X sur poudre utilisant Cu-Kα en tant que source de rayonnement, la forme cristalline de dibutyryladénosine cyclophosphate de calcium sans eau de cristallisation présente des pics caractéristiques à des positions où les angles de diffraction 2θ sont égaux à 12,3° ± 0,2°, 17,6° ± 0,2°, 21,4° ± 0,2°, 24,7° ± 0,2°, 25,3° ± 0,2° et 27,8° ± 0,2°. La forme cristalline de dibutyryladénosine cyclophosphate de calcium sans eau de cristallisation de la présente invention a une pureté élevée, et une bonne stabilité ; le procédé de préparation est simple et pratique, a une bonne reproductibilité, et est facile à populariser et appliquer à l'échelle industrielle.
(ZH)本发明公开了一种无结晶水二丁酰环磷腺苷钙晶型及其制备方法和应用。该无结晶水二丁酰环磷腺苷钙晶型在使用辐射源为Cu-Kα的粉末X-射线衍射图谱中,在衍射角2θ=12.3°±0.2°、17.6°±0.2、21.4°±0.2°、24.7°±0.2、25.3°±0.2°和27.8°±0.2°处有特征峰。本发明的无结晶水二丁酰环磷腺苷钙晶型纯度高、稳定性好、制备方法简便,而且重现性好,便于工业化推广应用。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)