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1. (WO2016100778) FUMAGILLOL DERIVATIVES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/100778    International Application No.:    PCT/US2015/066594
Publication Date: 23.06.2016 International Filing Date: 18.12.2015
IPC:
C07F 9/53 (2006.01), C07F 9/40 (2006.01), A61K 31/66 (2006.01)
Applicants: TAKEDA PHARMACEUTICAL COMPANY LIMITED [JP/JP]; 1-1, Doshomachi 4-chome, Chuo-ku Osaka-shi, Osaka 541-0045 (JP) (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
CHERUVALLATH, Zacharia [US/US]; (US) (US only).
LAWSON, John David [US/US]; (US) (US only).
MCBRIDE, Christopher [US/US]; (US) (US only)
Inventors: CHERUVALLATH, Zacharia; (US).
LAWSON, John David; (US).
MCBRIDE, Christopher; (US)
Agent: RUSSO, Matthew, J.; (US)
Priority Data:
62/094,823 19.12.2014 US
Title (EN) FUMAGILLOL DERIVATIVES
(FR) DÉRIVÉS DE FUMAGILLOL
Abstract: front page image
(EN)Disclosed are compounds of Formula (1), stereoisomers thereof and pharmaceutically acceptable salts of the compounds and stereoisomers, wherein R1 and R2 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula (1), to pharmaceutical compositions which contain them, and to their use for treating obesity and related diseases, disorders, and conditions associated with MetAP2.
(FR)L'invention concerne des composés de Formule (1), des stéréoisomères de ceux-ci et des sels pharmaceutiquement acceptables de ces composés et stéréoisomères. Dans ladite formule, R1 et R2 sont tels que définis dans la description. L'invention concerne également des substances et des procédés pour la préparation des composés de formule (1), des compositions pharmaceutiques les contenant, et enfin leur utilisation pour le traitement de l'obésité et d'affections, de troubles et d'états connexes associés à MetAP2.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)