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1. WO2016100738 - ANTIFIBROTIC ACTIVITY OF GAS6 INHIBITOR

Publication Number WO/2016/100738
Publication Date 23.06.2016
International Application No. PCT/US2015/066498
International Filing Date 17.12.2015
IPC
C07K 14/705 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
C07K 16/18 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
A61K 38/16 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
CPC
A61K 38/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
A61K 38/45
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
45Transferases (2)
A61K 39/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies
C12Y 207/10001
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
YENZYMES
207Transferases transferring phosphorus-containing groups (2.7)
10Protein-tyrosine kinases (2.7.10)
10001Receptor protein-tyrosine kinase (2.7.10.1)
Applicants
  • ARAVIVE BIOLOGICS, INC. [US]/[US]
  • THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Inventors
  • TABIBIAZAR, Raymond
  • GIACCIA, Amato J.
  • KARIOLIS, Mihalis
  • MIAO, Yu Rebecca
Agents
  • SHERWOOD, Pamela J.
Priority Data
62/093,93718.12.2014US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ANTIFIBROTIC ACTIVITY OF GAS6 INHIBITOR
(FR) ACTIVITÉ ANTIFIBROTIQUE D'INHIBITEUR DE GAS6
Abstract
(EN)
Compositions and methods are provided for treating fibrosis in a mammal by administering a therapeutic dose of a pharmaceutical composition that inhibits AXL, MER or Tyro3 protein activity, for example by inhibition of the binding interaction between AXL, MER or Tyro3 and its ligand GAS6.
(FR)
Cette invention concerne des compositions et des méthodes de traitement de la fibrose chez un mammifère par administration d'une dose thérapeutique d'une composition pharmaceutique qui inhibe l'activité protéique d'AXL, MER ou Tyro3, par exemple par inhibition de l'interaction de liaison entre AXL, MER ou Tyro3 et son ligand GAS6.
Latest bibliographic data on file with the International Bureau