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1. WO2016100302 - SOLID FORMS COMPRISING (1E, 4E)-2-AMINO-N,N-DIPROPYL-8-(4-(PYRROLIDINE-1-CARBONYL)PHENYL)-3H-BENZO[B]AZEPINE-4-CARBOXAMIDE, COMPOSITIONS THEREOF, AND USES THEREOF

Publication Number WO/2016/100302
Publication Date 23.06.2016
International Application No. PCT/US2015/065755
International Filing Date 15.12.2015
IPC
A61K 31/55 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
CPC
A61K 31/55
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07B 2200/13
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
2200Indexing scheme relating to specific properties of organic compounds
13Crystalline forms, e.g. polymorphs
C07D 223/16
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
223Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
14condensed with carbocyclic rings or ring systems
16Benzazepines; Hydrogenated benzazepines
C07D 403/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
02containing two hetero rings
10linked by a carbon chain containing aromatic rings
Applicants
  • CELGENE CORPORATION [US]/[US]
Inventors
  • MAN, Hon-Wah
  • FITZPATRICK, Timothy, D.
  • FRANK, Anthony
  • LI, Ying
  • LU, Xiaoling
  • BEAUCHAMPS, Marie, G.
  • FERRETTI, Antonio, C.
Agents
  • RIEGER, Dale L.
Priority Data
62/092,76416.12.2014US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) SOLID FORMS COMPRISING (1E, 4E)-2-AMINO-N,N-DIPROPYL-8-(4-(PYRROLIDINE-1-CARBONYL)PHENYL)-3H-BENZO[B]AZEPINE-4-CARBOXAMIDE, COMPOSITIONS THEREOF, AND USES THEREOF
(FR) FORMES SOLIDES COMPRENANT DU (1E,4E)-2-AMINO-N,N-DIPROPYL-8-(4- (PYRROLIDINE-1-CARBONYL)PHÉNYL)-3H-BENZO[B]AZÉPINE-4-CARBOXAMIDE, LEURS COMPOSITIONS ET UTILISATIONS
Abstract
(EN) Provided herein are compositions including the crystalline forms of (IE, 4E)-2- amino-N,N-dipropyl -8-(4-(pyrrol i dine-l -carbonyl) phenyl)-3H-benzo[b]azepine-4-carboxamide ("Compound A"), methods of making the crystalline forms, and methods of using the crystalline forms for the treatment of diseases, including, for example, cancer. Provided herein are crystalline forms of the compound having formula (I). ((1E,4E)-2-amino-N;N-dipropyl-8-(4-(pyrrolidine- 1 -carbonyl)phenyl)-3Hbenzo[b]azepine-4-carboxamide ("Compound A")). The crystalline form can be an unsolvated or solvated crystalline form of the compound of formula (I).
(FR) Cette invention concerne des compositions contenant les formes cristallines du (1E,4E)-2-amino-N,N-dipropyl-8-(4-(pyrrolidine-1-carbonyl)phényl)-3H-benzo[b]azépine-4-carboxamide ("Composé A"), des procédés de préparation desdites formes cristallines, et des méthodes pour les utiliser dans le traitement de maladies, comprenant, par exemple, le cancer.
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