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1. (WO2016100184) GEMINAL SUBSTITUTED QUINUCLIDINE AMIDE COMPOUNDS AS AGONISTS OF ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/100184    International Application No.:    PCT/US2015/065497
Publication Date: 23.06.2016 International Filing Date: 14.12.2015
IPC:
A61K 31/519 (2006.01), A61P 25/22 (2006.01)
Applicants: AXOVANT SCIENCES GMBH; c/o Vischer AG, Aeschenvorstadt 4 CH-4010 Basel (CH)
Inventors: ACHARYA, Raksha; (US).
BURNETT, Duane, A.; (US).
BURSAVICH, Matthew, Gregory; (US).
COOK, Andrew, Simon; (US).
HARRISON, Bryce, Alden; (US).
KOENIG, Gerhard; (US).
MCRINER, Andrew, J.; (US)
Agent: SHARER, Paul, L.; (US)
Priority Data:
62/167,706 28.05.2015 US
62/092,702 16.12.2014 US
Title (EN) GEMINAL SUBSTITUTED QUINUCLIDINE AMIDE COMPOUNDS AS AGONISTS OF ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTORS
(FR) COMPOSÉS AMIDE DE QUINUCLIDINE À SUBSTITUANTS GÉMINAL, EN TANT QU'AGONISTES DES RÉCEPTEURS NICOTINIQUES DE L'ACÉTYLCHOLINE Α7
Abstract: front page image
(EN)The present invention relates to novel geminal substituted quinuclidine amide compounds, and pharmaceutical compositions of the same, that are suitable as agonists or partial agonists of α7- nAChR, and methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering the compound or composition to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom.
(FR)La présente invention concerne des nouveaux composés amide de quinuclidine à substituants géminal, et des compositions pharmaceutiques de ceux-ci, appropriés en tant qu'agonistes ou agonistes partiels d'a7-nAChR, des procédés de préparation de ces composés et compositions, et leur utilisation dans des procédés de conservation, de traitement et/ou d'amélioration de la fonction cognitive. En particulier, l'invention concerne des méthodes d'administration dudit composé ou de ladite composition à un patient nécessitant un tel traitement, par exemple un patient atteint d'une déficience cognitive et/ou désireux d'améliorer sa fonction cognitive, susceptible d'en tirer un bénéfice.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)