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1. (WO2016099887) COMPOSITIONS AND METHODS FOR EFFICIENT GENE EDITING IN E. COLI USING GUIDE RNA/CAS ENDONUCLEASE SYSTEMS IN COMBINATION WITH CIRCULAR POLYNUCLEOTIDE MODIFICATION TEMPLATES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/099887    International Application No.:    PCT/US2015/063434
Publication Date: 23.06.2016 International Filing Date: 02.12.2015
IPC:
C12N 9/22 (2006.01), C12N 15/10 (2006.01), C12N 15/70 (2006.01)
Applicants: E. I. DU PONT DE NEMOURS AND COMPANY [US/US]; Chestnut Run Plaza 974 Centre Road P.O. Box 2915 Wilmington, Delaware 19805 (US)
Inventors: FRISCH, Ryan, L.; (US).
JACKSON, Ethel, Noland; (US)
Agent: STOOP, Johan, M.; (US)
Priority Data:
62/092,914 17.12.2014 US
Title (EN) COMPOSITIONS AND METHODS FOR EFFICIENT GENE EDITING IN E. COLI USING GUIDE RNA/CAS ENDONUCLEASE SYSTEMS IN COMBINATION WITH CIRCULAR POLYNUCLEOTIDE MODIFICATION TEMPLATES
(FR) COMPOSITIONS ET PROCÉDÉS POUR L'ÉDITION DE GÈNES EFFICACE DANS E COLI AU MOYEN DE SYSTÈMES D'ARN GUIDE/ENDONUCLÉASE CAS EN COMBINAISON AVEC DES MATRICES DE MODIFICATION DE POLYNUCLÉOTIDE CIRCULAIRE
Abstract: front page image
(EN)Compositions and methods are provided for genome modification of a target sequence in the genome of an Escherichia coli cell. The methods and compositions employ a guide RNA/Cas endonuclease system in combination with a circular polynucleotide modification template to provide an effective system for editing target sites within the genome of an Escherichia coli cell.
(FR)La présente invention concerne des compositions et des procédés de modification de génome d'une séquence cible dans le génome d'une cellule d'Escherichia coli. Les procédés et les compositions utilisent un système d'ARN guide/endonucléase Cas en combinaison avec une matrice de modification de polynucléotide circulaire pour fournir un système efficace d'édition de sites cibles dans le génome d'une cellule d'Escherichia coli.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)