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1. (WO2016099673) NANOPORE-BASED SEQUENCING WITH VARYING VOLTAGE STIMULUS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/099673    International Application No.:    PCT/US2015/058533
Publication Date: 23.06.2016 International Filing Date: 01.11.2015
IPC:
G01N 27/447 (2006.01)
Applicants: GENIA TECHNOLOGIES, INC. [US/US]; 2841 Scott Boulevard Santa Clara, CA 95050 (US) (US only).
F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 4070 Basel (CH) (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
ROCHE DIAGNOSTICS GMBH [DE/DE]; Sandhofer Strasse 116 68305 Mannheim (DE) (DE only)
Inventors: CHEN, Roger, J., A.; (US).
TIAN, Hui; (US).
MANEY, Bill; (US)
Agent: TONG, Grace, C.; (US)
Priority Data:
14/577,511 19.12.2014 US
Title (EN) NANOPORE-BASED SEQUENCING WITH VARYING VOLTAGE STIMULUS
(FR) SÉQUENÇAGE À BASE DE NANOPORE AVEC STIMULUS DE TENSION VARIABLE
Abstract: front page image
(EN)A method of analyzing a molecule in a nanopore is disclosed. A voltage is applied across a nanopore that is inserted in a membrane by coupling the nanopore to a voltage source. The nanopore is decoupled from the voltage source. After the decoupling, a rate of decay of the voltage across the nanopore is determined. A molecule in the nanopore is distinguished from other possible molecules based on the determined rate of decay of the voltage across the nanopore.
(FR)L'invention concerne un procédé d'analyse d'une molécule dans un nanopore. Une tension est appliquée sur un nanopore qui est introduit dans une membrane par couplage du nanopore à une source de tension. Le nanopore est découplé de la source de tension. Après le découplage, un taux d'abaissement de la tension sur le nanopore est déterminé. Une molécule dans le nanopore est distinguée d'autres molécules possibles sur la base du taux d'abaissement déterminé de la tension sur le nanopore.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)