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1. (WO2016099311) SUBSTITUTED AMINO TRIAZOLES USEFUL AS ACIDIC MAMMALIAN CHITINASE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/099311    International Application No.:    PCT/PL2015/050071
Publication Date: 23.06.2016 International Filing Date: 18.12.2015
IPC:
C07D 401/14 (2006.01), C07D 401/04 (2006.01), A61K 31/454 (2006.01), A61P 11/06 (2006.01), A61P 37/08 (2006.01)
Applicants: ONCOARENDI THERAPEUTICS S.A. [--/PL]; Zwirki i Wigury 02-089 Warszawa (PL)
Inventors: GOŁĘBIOWSKI, Adam A.; (US).
KORALEWSKI, Robert; (PL).
CZESTKOWSKI, Wojciech; (PL).
MATYSZEWSKI, Krzysztof; (PL).
OLEJNICZAK, Sylwia; (PL).
OLCZAK, Jacek; (PL).
BECKETT, Paul R.; (US)
Agent: KICIAK, Krzysztof; (PL)
Priority Data:
62/094,446 19.12.2014 US
415073 04.12.2015 PL
14/959,369 04.12.2015 US
Title (EN) SUBSTITUTED AMINO TRIAZOLES USEFUL AS ACIDIC MAMMALIAN CHITINASE INHIBITORS
(FR) TRIAZOLES AMINO SUBSTITUÉS UTILES EN TANT QU'INHIBITEURS DE CHITINASES MAMMALIENNES ACIDES
Abstract: front page image
(EN)Disclosed are amino triazole compounds substituted by a carboxylate functional group or an bioisosteric polar functional group. Compounds having the carboxylate moiety or carboxylate bioisostere inhibit acidic mammalian chitinase. Also provided are methods of using the compounds to treat asthma reactions caused by allergens.
(FR)L'invention concerne des composés de triazole aminés substitués par un groupe fonctionnel carboxylate ou un groupe fonctionnel polaire bio-isostère. Les composés ayant la fraction carboxylate ou un bio-isostère carboxylate inhibent la chitinase mammalienne acide. L'invention concerne également des procédés d'utilisation de ces composés pour traiter des réactions d'asthme provoquées par des allergènes.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)