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1. (WO2016099214) COMPOSITION FOR ALLEVIATING NEPHROTOXICITY CAUSED BY IMMUNOSUPPRESSIVE DRUG, CONTAINING METFORMIN, AND COMPOSITION FOR PREVENTING OR TREATING IMMUNE DISEASES, CONTAINING SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/099214    International Application No.:    PCT/KR2015/013977
Publication Date: 23.06.2016 International Filing Date: 18.12.2015
IPC:
A61K 31/155 (2006.01), A61K 38/13 (2006.01), A61P 13/12 (2006.01), A61P 29/00 (2006.01)
Applicants: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION [KR/KR]; Songeui Campus, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul 06591 (KR)
Inventors: CHO, Mi La; (KR).
YANG, Chul Woo; (KR).
CHOI, Jong Young; (KR).
PARK, Sung Hwan; (KR).
PARK, Min Jung; (KR).
LEE, Seon Yeong; (KR).
JHUN, Joo Yeon; (KR).
LEE, Eun Jung; (KR).
KIM, Jae Kyung; (KR).
KIM, Eun Kyung; (KR).
LIM, Sun Woo; (KR)
Agent: BAE, KIM & LEE IP GROUP; 11th Floor, 343, Gangnam-daero, Seocho-gu, Seoul 06626 (KR)
Priority Data:
10-2014-0183462 18.12.2014 KR
10-2015-0179374 15.12.2015 KR
Title (EN) COMPOSITION FOR ALLEVIATING NEPHROTOXICITY CAUSED BY IMMUNOSUPPRESSIVE DRUG, CONTAINING METFORMIN, AND COMPOSITION FOR PREVENTING OR TREATING IMMUNE DISEASES, CONTAINING SAME
(FR) COMPOSITION POUR ATTÉNUER LA NÉPHROTOXICITÉ RÉSULTANT DE L'ADMINISTRATION DE MÉDICAMENT IMMUNOSUPPRESSEUR, CONTENANT DE LA METFORMINE, ET COMPOSITION POUR LA PRÉVENTION OU LE TRAITEMENT DE MALADIES IMMUNITAIRES LA CONTENANT
(KO) 메트포민을 포함하는 면역억제제로 인한 신장 독성 완화용 조성물 및 이를 포함하는 면역질환 예방 또는 치료용 조성물
Abstract: front page image
(EN)The present invention relates to a composition for alleviating nephrotoxicity caused by an immunosuppressive drug, containing metformin, and a composition for preventing or treating immune diseases, containing the same and, more specifically, to a composition for reducing nephrotoxicity caused by an immunosuppressive drug, containing metformin as an active ingredient, a pharmaceutical composition for preventing or treating immune diseases, containing metformin and a calcineurin inhibitor as active ingredients, and a pharmaceutically combined preparation for preventing or treating immune diseases, containing metformin and a calcineurin inhibitor as constituent elements, wherein the metformin and the calcineurin inhibitor are administered simultaneously, individually or in a predetermined order. The composition of the present invention can be useful for improving a treatment effect on diseases requiring immunosuppression by effectively alleviating the deterioration of a renal function caused by side effects of a conventional immunosuppressive drug, and further, can be useful for preventing or treating organ transplant rejection, autoimmune diseases, inflammatory diseases and the like since nephrotoxicity side effects of a conventional immunosuppressive drug is reduced and the immunosuppressive or immunomodulatory effects are maximized by suggesting various methods for co-administering a conventional immunosuppressive drug and metformin.
(FR)La présente invention concerne une composition destinée à atténuer la néphrotoxicité due à un médicament immunosuppresseur, contenant de la metformine, et une composition pour prévenir ou traiter les maladies immunitaires contenant ladite composition et, plus particulièrement, une composition permettant de réduire la néphrotoxicité provoquée par un médicament immunosuppresseur, contenant de la metformine comme principe actif, une composition pharmaceutique pour la prévention ou le traitement de maladies immunitaires, contenant de la metformine et un inhibiteur de la calcineurine en tant qu'ingrédients actifs, et une préparation pharmaceutiquement combinée pour prévenir ou traiter des maladies immunitaires, contenant de la metformine et un inhibiteur de la calcineurine en tant qu'éléments constitutifs, la metformine et l'inhibiteur de la calcineurine étant administrés simultanément, individuellement ou dans un ordre prédéterminé. La composition de la présente invention peut être utile pour améliorer un effet thérapeutique sur des maladies nécessitant une immunosuppression en soulageant efficacement la détérioration d'une fonction rénale provoquée par des effets secondaires d'un médicament immunosuppresseur classique, et en outre, peut être utile pour prévenir ou traiter le rejet de greffe d'organe, des maladies auto-immunes, des maladies inflammatoires et équivalents, étant donné que les effets indésirables de néphrotoxicité d'un médicament immunosuppresseur classique sont réduits et que les effets immunosuppresseurs ou immunomodulateurs sont maximisés en suggérant divers procédés de co-administration d'un médicament immunosuppresseur classique et de metformine.
(KO)본 발명은 메트포민(metformin)을 포함하는 면역억제제로 인한 신장 독성 완화용 조성물 및 이를 포함하는 면역질환 예방 또는 치료용 조성물에 관한 것으로, 보다 상세하게는 메트포민을 유효성분으로 포함하는 면역억제제로 유발된 신장 독성 감소용 조성물, 메트포민과 칼시뉴린 억제제(calcineurin inhibitor)를 유효성분으로 포함하는 면역질환의 예방 또는 치료용 약학적 조성물 및 메트포민과 칼시뉴린 억제제를 구성요소로 포함하며 이들을 동시에, 개별적으로 또는 정해진 순서로 투여하는 것을 특징으로 하는 면역질환의 예방 또는 치료용 약학적 복합 제제에 관한 것이다. 본 발명의 조성물은 기존 면역억제제의 부작용으로 생기는 신장 기능 저하를 효과적으로 완화하여 면역억제가 필요한 질병의 치료 효과를 높이는데 유용하게 이용될 수 있으며, 더 나아가 기존의 면역억제제와 메트포민을 병용투여하는 다양한 방법을 제시하여 기존 면역억제제의 신장 독성 부작용은 줄이고, 면역억제 또는 면역조절 효과는 극대화함으로써, 장기이식 거부 반응, 자가면역질환, 염증성 질환 등을 예방하거나 치료하는데 유용하게 이용될 수 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)