WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2016099188) PEPTIDE HAVING EIGHT AMINO ACID SEQUENCES DERIVED FROM CAGE AND RETAINING ANTICANCER ACTIVITY AND ACTIVITY TO PROMOTE ANTICANCER DRUG SENSITIVITY OF ANTICANCER DRUG-RESISTANT CANCER CELLS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/099188    International Application No.:    PCT/KR2015/013920
Publication Date: 23.06.2016 International Filing Date: 18.12.2015
IPC:
C07K 7/06 (2006.01), A61K 38/08 (2006.01), A61P 35/00 (2006.01)
Applicants: L-BASE CO.,LTD. [KR/KR]; 4F. 296, Dobong-ro Gangbuk-gu Seoul 01062 (KR)
Inventors: JEOUNG, Doo Il; (KR).
KIM, Young Mi; (KR).
KIM, Hyun A; (KR)
Agent: KIM, Tae Sun; 4F. Sanglok building 148 Gangnam-daero Seocho-gu Seoul 06748 (KR)
Priority Data:
10-2014-0183218 18.12.2014 KR
Title (EN) PEPTIDE HAVING EIGHT AMINO ACID SEQUENCES DERIVED FROM CAGE AND RETAINING ANTICANCER ACTIVITY AND ACTIVITY TO PROMOTE ANTICANCER DRUG SENSITIVITY OF ANTICANCER DRUG-RESISTANT CANCER CELLS
(FR) PEPTIDE AYANT HUIT SÉQUENCES D'ACIDES AMINÉS DÉRIVÉES DE CAGE ET CONSERVANT UNE ACTIVITÉ ANTICANCÉREUSE ET UNE ACTIVITÉ VISANT À PROMOUVOIR LA SENSIBILITÉ À UN MÉDICAMENT ANTICANCÉREUX DE CELLULES CANCÉREUSES RÉSISTANT À DES MÉDICAMENTS ANTI-CANCÉREUX
(KO) CAGE 유래 8개의 아미노산 서열을 갖으며 항암활성 및 항암제 내성 암세포의 항암제에 대한 감수성 증진 활성을 갖는 펩티드
Abstract: front page image
(EN)The present invention relates to a peptide having eight amino acid sequences derived from CAGE and retaining anticancer activity and activity to promote anticancer drug sensitivity of anticancer drug resistant cancer cells and, specifically, to a peptide, which has an amino acid sequence of SEQ ID NO: 1 (AQTGTGKT) and thus binds to the CAGE protein, thereby inhibiting an inter-linkage between CAGE and GSK3β, thus exhibiting anticancer activity and activity to promote anticancer drug sensitivity of anticancer drug resistant cancer cells, and to a pharmaceutical composition, containing the peptide, for anticancer use or anticancer drug aiding.
(FR)La présente invention concerne un peptide ayant huit séquences d'acides aminés dérivés de CAGE et conservant une activité anticancéreuse et une activité visant à promouvoir la sensibilité à un médicament anticancéreux de cellules cancéreuses résistantes à des médicaments anticancéreux. L'invention concerne spécifiquement un peptide qui comprend une séquence d'acides aminés correspondant à SEQ ID NO : 1 (AQTGTGKT) et, de ce fait, se lie à la protéine CAGE, inhibant ainsi une liaison réciproque entre CAGE et GSK3β et présentant de ce fait une activité anti-cancéreuse et une activité pour favoriser la sensibilité à un médicament anticancéreux de cellules cancéreuses résistantes à des médicaments anticancéreux; et une composition pharmaceutique contenant le peptide, destinée à une utilisation anticancéreuse ou à assister un médicament anticancéreux.
(KO)본 발명은 CAGE 유래 8개의 아미노산 서열을 갖으며 항암활성 및 항암제 내성 암세포의 항암제에 대한 감수성 증진 활성을 갖는 펩티드에 관한 것으로, 구체적으로 서열번호 1(AQTGTGKT)의 아미노산 서열을 갖고 있어 CAGE 단백질에 결합하여 CAGE와 GSK3β의 상호결합을 저해함으로써 항암활성 및 항암제 내성 암세포의 항암제에 대한 감수성 증진 활성을 나타내는 펩티드, 이 펩티드를 함유하는 항암용 또는 항암제 보조용 약제학적 조성물에 관한 것이다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)