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1. WO2016098080 - INTEGRATING NANOPORE SENSORS WITHIN MICROFLUIDIC CHANNEL ARRAYS USING CONTROLLED BREAKDOWN

Publication Number WO/2016/098080
Publication Date 23.06.2016
International Application No. PCT/IB2015/059799
International Filing Date 18.12.2015
IPC
G01N 27/40 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
27Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means
26by investigating electrochemical variables; by using electrolysis or electrophoresis
28Electrolytic cell components
40Semi-permeable membranes or partitions
B81B 3/00 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
81MICROSTRUCTURAL TECHNOLOGY
BMICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
3Devices comprising flexible or deformable elements, e.g. comprising elastic tongues or membranes
CPC
B01D 2325/02
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
2325Details relating to properties of membranes
02Details relating to pores or pososity of the membranes
B81B 3/00
BPERFORMING OPERATIONS; TRANSPORTING
81MICROSTRUCTURAL TECHNOLOGY
BMICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
3Devices comprising flexible or deformable elements, e.g. comprising elastic tongues or membranes
B81B 3/0018
BPERFORMING OPERATIONS; TRANSPORTING
81MICROSTRUCTURAL TECHNOLOGY
BMICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
3Devices comprising flexible or deformable elements, e.g. comprising elastic tongues or membranes
0018Structures acting upon the moving or flexible element for transforming energy into mechanical movement or vice versa, i.e. actuators, sensors, generators
C25F 3/14
CCHEMISTRY; METALLURGY
25ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
FPROCESSES FOR THE ELECTROLYTIC REMOVAL OF MATERIALS FROM OBJECTS; APPARATUS THEREFOR
3Electrolytic etching or polishing
02Etching
14locally
C25F 7/00
CCHEMISTRY; METALLURGY
25ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
FPROCESSES FOR THE ELECTROLYTIC REMOVAL OF MATERIALS FROM OBJECTS; APPARATUS THEREFOR
7Constructional parts, or assemblies thereof, of cells for electrolytic removal of material from objects
G01N 27/3278
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
27Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means
26by investigating electrochemical variables; by using electrolysis or electrophoresis
28Electrolytic cell components
30Electrodes, e.g. test electrodes; Half-cells
327Biochemical electrodes ; electrical and mechanical details of in vitro measurements
3275Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
3278involving nanosized elements, e.g. nanogaps or nanoparticles
Applicants
  • THE UNIVERSITY OF OTTAWA [CA]/[CA]
Inventors
  • TABARD-COSSA, Vincent
  • GODIN, Michel
  • TAHVILDARI, Radin
  • BEAMISH, Eric
Priority Data
62/094,66919.12.2014US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) INTEGRATING NANOPORE SENSORS WITHIN MICROFLUIDIC CHANNEL ARRAYS USING CONTROLLED BREAKDOWN
(FR) INTÉGRATION DE CAPTEURS À NANOPORES À L'INTÉRIEUR DE RÉSEAUX DE CANAUX MICROFLUIDIQUES À L'AIDE DU CLAQUAGE CONTRÔLÉ
Abstract
(EN)
Nanopore arrays are fabricated by controlled breakdown in solid-state membranes integrated within polydimethylsiloxane (PDMS) microfluidic devices. This technique enables the scalable production of independently addressable nanopores. By confining the electric field within the microfluidic architecture, nanopore fabrication is precisely localized and electrical noise is significantly reduced during sensing.
(FR)
Des réseaux de nanopores sont fabriqués par claquage contrôlé dans des membranes à semi-conducteurs intégrées à l'intérieur de dispositifs microfluidiques de polydiméthylsiloxane (PDMS). Cette technique permet la production évolutive de nanopores indépendamment adressables. Par confinement du champ électrique à l'intérieur de l'architecture microfluidique, la fabrication de nanopores est précisément localisée et le bruit électrique est réduit de manière significative pendant la détection.
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