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Machine translation
1. (WO2016097749) PARG INHIBITORY COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/097749    International Application No.:    PCT/GB2015/054064
Publication Date: 23.06.2016 International Filing Date: 17.12.2015
IPC:
C07D 413/14 (2006.01), C07D 401/06 (2006.01), C07D 235/26 (2006.01), C07D 403/06 (2006.01), C07D 405/04 (2006.01), C07D 405/06 (2006.01), C07D 409/04 (2006.01), C07D 413/04 (2006.01), C07D 413/06 (2006.01), C07D 417/04 (2006.01), C07D 417/06 (2006.01), C07D 417/14 (2006.01)
Applicants: CANCER RESEARCH TECHNOLOGY LIMITED [GB/GB]; Angel Building 407 St John Street London EC1V 4AD (GB)
Inventors: MCGONAGLE, Alison E.; (GB).
JORDAN, Allan M.; (GB).
WASZKOWYCZ, Bohdan; (GB).
HUTTON, Colin P.; (GB).
WADDELL, Ian D.; (GB).
HITCHIN, James R.; (GB).
SMITH, Kate M.; (GB).
HAMILTON, Niall M.; (GB)
Agent: WELLS, Andrew; (GB)
Priority Data:
1422771.4 19.12.2014 GB
Title (EN) PARG INHIBITORY COMPOUNDS
(FR) COMPOSÉS INHIBITEURS DE PARG
Abstract: front page image
(EN)The present invention relates to compounds of formula I that function as inhibitors of PARG (Poly ADP-ribose glycohydrolase) enzyme activity: wherein R1a, R1b, R1c, R1d, R1e, W, X1, X2, X3, X4, X5, X6, X7, c are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PARG activity is implicated.
(FR)La présente invention concerne des composés de la formule I qui fonctionnent en tant qu'inhibiteurs de l'activité enzymatique PARG (Poly ADP-ribose glycohydrolase) : dans ladite formule, R1a, R1b, R1c, R1d, R1e, W, X1, X2, X3, X4, X5, X6, X7, c sont chacun tels que définis dans la description. La présente invention concerne également des procédés de préparation de ces composés, des compositions pharmaceutiques les comprenant et leur utilisation dans le traitement de troubles prolifératifs, tels que le cancer, ainsi que d'autres maladies ou états dans lesquels est impliquée l'activité PARG.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)