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1. (WO2016097389) BENZENESULFONAMIDE DERIVATIVES AS INVERSE AGONISTS OF RETINOID-RELATED ORPHAN RECEPTOR GAMMA (ROR GAMMA (T))
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/097389    International Application No.:    PCT/EP2015/080687
Publication Date: 23.06.2016 International Filing Date: 18.12.2015
Chapter 2 Demand Filed:    19.10.2016    
IPC:
C07D 417/06 (2006.01), C07D 309/06 (2006.01), C07D 309/04 (2006.01), C07D 307/93 (2006.01), C07D 261/08 (2006.01), C07D 211/22 (2006.01), C07D 211/46 (2006.01), C07D 213/30 (2006.01), C07D 279/16 (2006.01), C07D 305/06 (2006.01), C07D 305/08 (2006.01), C07D 335/02 (2006.01), C07D 309/12 (2006.01), C07D 333/48 (2006.01), C07C 311/29 (2006.01), C07D 263/20 (2006.01), C07D 263/24 (2006.01), C07D 271/08 (2006.01), C07D 207/26 (2006.01), C07D 295/096 (2006.01), C07D 211/76 (2006.01), C07D 211/96 (2006.01), A61K 31/351 (2006.01), A61P 17/00 (2006.01)
Applicants: GALDERMA RESEARCH & DEVELOPMENT [FR/FR]; 2400 Route des Colles Les Templiers 06410 Biot (FR)
Inventors: MUSICKI, Branislav; (FR).
OUVRY, Gilles; (FR).
THOREAU, Etienne; (FR).
BOUIX-PETER, Claire; (FR)
Agent: CASALONGA & ASSOCIES; 8 Avenue Percier 75008 Paris (FR)
Priority Data:
1463034 19.12.2014 FR
1556629 10.07.2015 FR
Title (EN) BENZENESULFONAMIDE DERIVATIVES AS INVERSE AGONISTS OF RETINOID-RELATED ORPHAN RECEPTOR GAMMA (ROR GAMMA (T))
(FR) DÉRIVÉS BENZÈNESULFONAMIDES EN TANT QU'AGONISTES INVERSES DU RÉCEPTEUR GAMMA ORPHELIN ASSOCIÉ AUX RÉTINOÏDES ROR GAMMA (T)
Abstract: front page image
(EN)The invention relates to benzenesulfonamide derivatives of formula (I), the pharmaceutically acceptable addition salts thereof, the hydrates and/or solvates thereof, and the use of same as inverse agonists of retinoid-related orphan receptor gamma (RORγt). The invention also relates to pharmaceutical compositions comprising such compounds, as well as to the use thereof for the topical and/or oral treatment of RORγt receptor-mediated inflammatory diseases, in particular acne, psoriasis and/or atopic dermatitis.
(FR)La présente invention concerne des dérivés benzènesulfonamides de formule (I), leurs sels d'addition pharmaceutiquement acceptables, leurs hydrates et/ou leurs solvates, ainsi que leur utilisation en tant qu'agonistes inverses du récepteur gamma orphelin associé aux rétinoïdes RORyt. L'invention est également relative aux compositions pharmaceutiques comprenant de tels composés, ainsi que leur utilisation pour le traitement par voie topique et/ou orale des maladies inflammatoires médiées par les récepteurs RORyt, notamment l'acné, le psoriasis et/ ou la dermatite atopique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: French (FR)
Filing Language: French (FR)