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1. (WO2016097351) 18F LABELLED THIAZOLYLHYDRAZONE DERIVATIVES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/097351    International Application No.:    PCT/EP2015/080609
Publication Date: 23.06.2016 International Filing Date: 18.12.2015
IPC:
C07D 417/12 (2006.01), A61K 32/4439, A61P 25/16 (2006.01), A61P 25/28 (2006.01)
Applicants: GE HEALTHCARE LIMITED [GB/GB]; Amersham Place Little Chalfont Buckinghamshire HP7 9NA (GB)
Inventors: JACKSON, Alexander; (GB).
MORISSON-IVESON, Veronique; (GB).
WYNN, Duncan, George; (GB).
JOSE, Jinto; (IN).
RANGASWAMY, Chitralekha; (IN)
Agent: BANNAN, Sally; (GB)
Priority Data:
1422758.1 19.12.2014 GB
975/DEL/2015 06.04.2015 IN
Title (EN) 18F LABELLED THIAZOLYLHYDRAZONE DERIVATIVES
(FR) DÉRIVÉS DE THIAZOLYLHYDRAZONE MARQUÉS AU 18F
Abstract: front page image
(EN)The present invention relates to compounds of Formula (I) wherein R1 and R2 are independently selected from 19F and 18F having selective binding for MAO-B as compared with MAO-A. The invention also provides radioactive versions of these compounds, and precursor compounds for the synthesis of these radioactive compounds. The radioactive compounds of the invention can find use for in vivo imaging applications.
(FR)La présente invention concerne des composés de formule (I) dans laquelle R1 et R2 sont choisis, indépendamment l'un de l'autre, parmi le 19F et le 18F possédant une liaison sélective pour la MAO-B plutôt que pour la MAO-A. L'invention concerne également des versions radioactives de ces composés et des composés précurseurs utilisables en vue de la synthèse de ces composés radioactifs. Les composés radioactifs de cette invention peuvent être utilisés dans des applications d'imagerie in vivo.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)