WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2016096938) CHIRAL TOXICITY SCREENING METHOD
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/096938    International Application No.:    PCT/EP2015/079915
Publication Date: 23.06.2016 International Filing Date: 16.12.2015
IPC:
C12N 15/11 (2006.01), C12N 15/113 (2010.01)
Applicants: ROCHE INNOVATION CENTER COPENHAGEN A/S [DK/DK]; Fremtidsvej 3 2970 Hørsholm (DK)
Inventors: ALBAEK, Nanna; (DK).
GUBLER, Marcel; (CH).
HAGEDORN, Peter; (DK).
HANSEN, Henrik, Frydenlund; (DK).
KOCH, Troels; (DK).
MOISAN, Annie; (CH).
RAVN, Jacob; (DK).
ROSENBOHM, Christoph; (DK).
SEWING, Sabine; (CH)
Agent: TURNER, Mark; (CH)
Priority Data:
14198167.0 16.12.2014 EP
15182401.8 25.08.2015 EP
15191074.2 22.10.2015 EP
15191075.9 22.10.2015 EP
15191076.7 22.10.2015 EP
15195198.5 18.11.2015 EP
15195202.5 18.11.2015 EP
PCT/EP2015/076967 18.11.2015 EP
PCT/EP2015/076971 18.11.2015 EP
Title (EN) CHIRAL TOXICITY SCREENING METHOD
(FR) PROCÉDÉ DE DÉPISTAGE DE LA TOXICITÉ CHIRALE
Abstract: front page image
(EN)The invention relates to a method of identifying stereodefined phosphrothioate oligonucleotide variants with reduced toxicity by creating and screening libraries of stereodefined chiral phosphorothioate variants for compounds with reduced toxicity, either in vitro or in vivo.
(FR)L'invention concerne un procédé d'identification de variants d'oligonucléotides phosphorothioate stéréodéfinis ayant une toxicité réduite par création et criblage de banques de variants phosphorothioate chiraux stéréodéfinis pour rechercher des composés présentant une toxicité réduite, in vitro ou in vivo.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)