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1. (WO2016096778) BENZAZEPINE SULFONAMIDE COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/096778    International Application No.:    PCT/EP2015/079679
Publication Date: 23.06.2016 International Filing Date: 15.12.2015
IPC:
C07D 403/12 (2006.01), C07D 401/14 (2006.01), C07D 223/16 (2006.01), C07D 401/04 (2006.01), C07D 401/12 (2006.01), A61K 31/55 (2006.01), A61P 35/00 (2006.01), A61P 37/00 (2006.01)
Applicants: F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 4070 Basel (CH) (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
HOFFMANN-LA ROCHE INC. [US/US]; Great Notch, 150 Clove Road 8th Floor Little Falls, New Jersey 07424 (US) (US only)
Inventors: HOVES, Sabine; (DE).
KOERNER, Matthias; (DE).
WANG, Lisha; (CH).
YUN, Hongying; (CN).
ZHU, Wei; (CN).
ZHANG, Weixing; (CN)
Agent: KLOSTERMEYER RAUBER, Doerte; (CH)
Priority Data:
PCT/CN2014/094181 18.12.2014 CN
Title (EN) BENZAZEPINE SULFONAMIDE COMPOUNDS
(FR) COMPOSÉS SULFONAMIDE DE BENZAZÉPINE
Abstract: front page image
(EN)This invention relates to novel benzazepine sulfonamide compounds of the formula (I), wherein R4 or R5 is -SO2-NR7R8 and R1 to R8 and Y are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are TLR agonists and may therefore be useful as medicaments for the treatment of diseases such as cancer, autoimmune diseases, inflammation, sepsis, allergy, asthma, graft rejection, graft-versus-host disease, immunodeficiencies, and infectious diseases.
(FR)La présente invention concerne de nouveaux composés sulfonamide de benzazépine de formule (I), dans laquelle R4 ou R5 est -SO2-NR7R8 et R1 à R8 et Y sont tels que définis dans la description et les revendications, ainsi que leurs sels pharmaceutiquement acceptables. Lesdits composés sont des agonistes TLR et peuvent par conséquent être utiles en tant que médicaments pour le traitement de maladies telles que le cancer, les maladies auto-immunes, l'inflammation, la sepsis, l'allergie, l'asthme, le rejet de greffe, la maladie du greffon contre l'hôte, les immunodéficiences, et les maladies infectieuses.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)