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1. (WO2016096590) SYNTHETIC ENZYME MIMIC BASED ON A HISTIDINE SCAFFOLD
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/096590    International Application No.:    PCT/EP2015/079204
Publication Date: 23.06.2016 International Filing Date: 10.12.2015
IPC:
B01J 31/02 (2006.01), B01J 31/06 (2006.01), B01J 31/04 (2006.01), C12N 9/00 (2006.01)
Applicants: UNILEVER PLC [GB/GB]; a company registered in England and Wales under company no. 41424 of Unilever House, 100 Victoria Embankment London Greater London EC4Y 0DY (GB) (AE, AG, AU, BB, BH, BN, BW, BZ, CA, CY, EG, GB, GD, GH, GM, IE, IL, IN, KE, KN, LC, LK, LS, MT, MW, MY, NA, NG, NZ, OM, PG, QA, RW, SA, SC, SD, SG, SL, SZ, TT, TZ, UG, VC, ZA, ZM, ZW only).
UNILEVER N.V. [NL/NL]; Weena 455 3013 AL Rotterdam (NL) (AL, AM, AO, AT, AZ, BA, BE, BF, BG, BJ, BR, BY, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, ES, FI, FR, GA, GE, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IR, IS, IT, JP, KG, KM, KP, KR, KZ, LA, LR, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MX, MZ, NE, NI, NL, NO, PA, PE, PH, PL, PT, RO, RS, RU, SE, SI, SK, SM, SN, ST, SV, SY, TD, TG, TH, TJ, TM, TN, TR, UA, UZ, VN only).
CONOPCO, INC., D/B/A UNILEVER [US/US]; 800 Sylvan Avenue AG West, S. Wing Englewood Cliffs, New Jersey 07632 (US) (US only).
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street 12th Floor Oakland, California 94607-5200 (US)
Inventors: CONNAL, Luke, Andrew; (AU).
HAWKER, Craig, Jon; (US).
KHOSHDEL, Ezat; (GB).
PRESSLY, Eric, Dean; (US)
Agent: HARDY, Susan, Margaret; (GB)
Priority Data:
14198190.2 16.12.2014 EP
Title (EN) SYNTHETIC ENZYME MIMIC BASED ON A HISTIDINE SCAFFOLD
(FR) MIMÉTIQUE D'ENZYME SYNTHÉTIQUE À BASE D'UN ÉCHAFAUDAGE D'HISTIDINE
Abstract: front page image
(EN)A synthetic enzyme mimic comprising a support carrying at least one scaffold, the scaffold incorporating multiple functional groups comprising (i) a carboxylate group, (ii) an imidazole group; and (iii) a nucleophilic group such as an amino, hydroxy or thiol group; wherein the functional groups are arranged in close proximity. The invention also provides a process for making a synthetic enzyme, comprising the step of attaching a catalytic unit comprising said scaffold to a support such as a polymer by attachment of a reactive handle such as an azide group to the support and a matching reactive handle to the catalytic unit, in particular a terminal alkynyl group, to form a linker which is preferably an ether linker. Advantageously the attaching is done via click chemistry.
(FR)La présente invention concerne un mimétique d'enzyme synthétique comprenant un support portant au moins un échafaudage, l'échafaudage incorporant de multiples groupes fonctionnels comprenant (i) un groupe carboxylate, (ii) un groupe imidazole; et (iii) un groupe nucléophile, tel qu'un groupe amine, hydroxy ou thiol. Les groupes fonctionnels sont disposés à proximité immédiate. La présente invention concerne également un procédé de fabrication d'une enzyme synthétique, comprenant l'étape consistant à relier une unité catalytique comprenant un échafaudage à un support tel qu'un polymère par fixation d'une poignée réactive à l'unité catalytique, en particulier à un groupe alcynyle terminal, pour former un lieur qui est, de préférence, un lieur éther. De manière avantageuse, la liaison s'effectue par la chimie clic.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)