WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2016095642) INTERLEUKIN 15 PROTEIN COMPLEX AND USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/095642    International Application No.:    PCT/CN2015/094780
Publication Date: 23.06.2016 International Filing Date: 17.11.2015
IPC:
C07K 19/00 (2006.01), C12N 15/62 (2006.01), A61K 38/20 (2006.01), A61P 35/00 (2006.01), A61P 29/00 (2006.01), A61P 37/02 (2006.01), A61P 7/00 (2006.01), A61P 31/00 (2006.01), A61P 17/00 (2006.01), A61P 19/02 (2006.01), A61P 1/00 (2006.01)
Applicants: JIANGSU HENGRUI MEDICINE CO., LTD. [CN/CN]; No.7 Kunlunshan Road,, Economic and Technological Development Zone Lianyungang, Jiangsu 222047 (CN).
SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. [CN/CN]; No.279 Wenjing Road, Minhang District Shanghai 200245 (CN)
Inventors: QU, Xiangdong; (CN).
YE, Xin; (CN).
HU, Qiyue; (CN).
CUI, Dongbing; (CN).
TAO, Weikang; (CN).
ZHANG, Lianshan; (CN).
SUN, Piaoyang; (CN)
Agent: GE CHENG & CO.,LTD.; Level 19, Tower E3, The Towers, Oriental Plaza No.1 East Chang An Avenue, Dongcheng District Beijing 100738 (CN)
Priority Data:
201410799889.4 19.12.2014 CN
Title (EN) INTERLEUKIN 15 PROTEIN COMPLEX AND USE THEREOF
(FR) COMPLEXE PROTÉINE-INTERLEUKINE 15 ET UTILISATION ASSOCIÉE
(ZH) 白细胞介素15蛋白复合物及其用途
Abstract: front page image
(EN)Provided in the application is a interleukin 15 (IL-15) protein complex. The IL-15 protein complex consists of a soluble fusion proteins (I) and (II), wherein the fusion protein (I) is a IL-15 polypeptide or a functionality fragment thereof, and the fusion protein (II) is a IL-15Rα polypeptide or a functionality fragment thereof. There are one or more amino acid sites on the fusion proteins (I) or (II) were mutated to Cys, which were paired with the corresponding Cys mutated from the amino acid sites on the fusion proteins (II) or(I) to form disulfide bonds. The IL-15 protein complex can be used for tumour therapy.
(FR)La présente invention concerne un complexe protéine-interleukine 15 (IL -15). Le complexe protéine-IL-15 est constitué de protéines hybrides solubles (I) et (II), la protéine hybride (I) étant un polypeptide d'IL-15 ou un fragment de fonctionnalité de celui-ci, et la protéine hybride (II) étant un polypeptide d'IL-15Rα ou un fragment de fonctionnalité de celui-ci. Il existe un ou plusieurs sites d'acides aminés sur les protéines hybrides (I) ou (II) ayant subi une mutation en Cys qui ont été appariés avec la Cys mutée correspondante des sites d'acides aminés sur les protéines hybrides (II) ou (I) afin de former des liaisons disulfure. Le complexe protéine-IL-15 peut être utilisé pour une thérapie antitumorale.
(ZH)本申请提供了一种白细胞介素15(IL-15)蛋白复合物,所述IL-15蛋白复合物由可溶性融合蛋白(I)和可溶性融合蛋白(II)组成,其中融合蛋白(I)为IL-15多肽或其功能性片段,融合蛋白(I)为IL-15Rα多肽或其功能性片段。融合蛋白(I)或融合蛋白(II)上具有一个或多个氨基酸位点突变成Cys,与对应的融合蛋白(II)或融合蛋白(I)氨基酸位点上突变成的Cys配对形成二硫键。所述IL-15蛋白复合物可用于肿瘤治疗。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)