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1. (WO2016095087) USES OF CHLOROGENIC ACID IN PREPARATION OF MEDICINES FOR TREATING VITILIGO
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/095087    International Application No.:    PCT/CN2014/093854
Publication Date: 23.06.2016 International Filing Date: 15.12.2014
IPC:
A61K 31/216 (2006.01), A61P 17/00 (2006.01)
Applicants: SICHUAN JIUZHANG BIOLOGICAL SCIENCE AND TECHNOLOGY CO., LTD [CN/CN]; No.10,Second Keyuan South Road, High-Tech District Chengdu, Sichuan 610041 (CN)
Inventors: ZHANG, Jie; (CN).
ZHU, Lina; (CN).
HUANG, Wang; (CN)
Agent: GAOYUNG INTELLECTUAL PROPERTY AGENCY(GENERALPARTNERSHIP); The Yiguanmiao Post Office Box A-42 (Ph.D.Entrepreneur Park,No.5 Gaopeng Road), Hi-Tech Zone Chengdu, Sichuan 610041 (CN)
Priority Data:
Title (EN) USES OF CHLOROGENIC ACID IN PREPARATION OF MEDICINES FOR TREATING VITILIGO
(FR) UTILISATION DE L'ACIDE CHLOROGÉNIQUE DANS LA PRÉPARATION D'UN MÉDICAMENT INDIQUÉ POUR LE TRAITEMENT DU VITILIGO
(ZH) 绿原酸在制备治疗白癜风的药物中的用途
Abstract: front page image
(EN)Provides are uses of chlorogenic acid in the preparation of medicines for treating vitiligo. Experiments show that chlorogenic acid can alleviate pathological changes of a vitiligo model, reduce expression of TNF- and IL-4 in damaged skin, promote generation of melanocytes, and provide a theoretical basis for treating vitiligo in clinic by using chlorogenic acid.
(FR)L'invention concerne l'utilisation de l'acide chlorogénique dans la préparation d'un médicament indiqué pour le traitement du vitiligo. Les essais cliniques ont permis de démontrer que l'acide chlorogénique améliore les changements pathologiques modèles du vitiligo, qu'il diminue l'expression de TNF et IL-4 au niveau de l'endothélium tout en stimulant la production de mélanocytes. Par ailleurs, les paramétrages cliniques pour le traitement du vitiligo ont permis de poser des bases théoriques.
(ZH)提供了绿原酸在制备治疗白癜风的药物中的用途。试验表明,绿原酸能改善白癜风模型的病理变化,降低皮损处TNF-和IL-4的表达,促进黑素细胞的生成,为其临床治疗白癜风提供了理论依据。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)