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1. (WO2016095037) MODULATION AND DETECTION OF A NEURONAL ALTERNATIVE SPLICING REGULATORY NETWORK FOR TREATMENT AND DIAGNOSIS OF NEUROLOGICAL DISORDERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/095037    International Application No.:    PCT/CA2015/051328
Publication Date: 23.06.2016 International Filing Date: 15.12.2015
IPC:
C12N 5/071 (2010.01), A01K 67/027 (2006.01), A61K 31/7088 (2006.01), A61K 38/46 (2006.01), A61K 39/395 (2006.01), A61P 25/00 (2006.01), A61P 25/18 (2006.01), C12N 15/00 (2006.01), C12N 15/12 (2006.01), C12N 5/079 (2010.01), C12N 5/10 (2006.01), C12Q 1/00 (2006.01), C12Q 1/68 (2006.01), G01N 33/48 (2006.01), G06F 19/10 (2011.01)
Applicants: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO [CA/CA]; 100 College Street Toronto, Ontario M5G 1L5 (CA).
SINAI HEALTH SYSTEM [CA/CA]; 600 University Avenue Toronto, Ontario, M5G 1X5 (CA)
Inventors: BLENCOWE, Benjamin J.; (CA).
QUESNEL-VALLIERES, Mathieu; (CA).
IRIMIA, Manuel; (ES).
RAJ, Bushra; (CA).
CORDES, Sabine P.; (CA)
Agent: BERESKIN & PARR LLP/S.E.N.C.R.L., S.R.L.; Scotia Plaza 40 King Street West, 40th Floor Toronto, Ontario M5H 3Y2 (CA)
Priority Data:
62/093,192 17.12.2014 US
Title (EN) MODULATION AND DETECTION OF A NEURONAL ALTERNATIVE SPLICING REGULATORY NETWORK FOR TREATMENT AND DIAGNOSIS OF NEUROLOGICAL DISORDERS
(FR) MODULATION ET DÉTECTION D'UN RÉSEAU RÉGULATEUR D'ÉPISSAGE ALTERNATIF NEURONAL POUR LE TRAITEMENT ET LE DIAGNOSTIC DE TROUBLES NEUROLOGIQUES
Abstract: front page image
(EN)Methods for treatment and diagnosis of neurological disorders such as autism and autism spectrum disorder are disclosed. Also disclosed are modulators of alternative splicing regulators SRRM4 and/or SRRM3 for treating neurological disorders. Further disclosed are agents that modulate the expression of at least one splice variant for treating neurological disorders. Mouse models of neurological disorders having increased or decreased expression of SRRM4 and/or SRRM3 are also disclosed.
(FR)L'invention concerne des procédés pour le traitement et le diagnostic de troubles neurologiques, tels que l'autisme et un trouble du spectre de l'autisme. L'invention concerne également des modulateurs des régulateurs d'épissage alternatif SRRM4 et/ou SRRM3 pour le traitement de troubles neurologiques. En outre, l'invention concerne des agents qui modulent l'expression d'au moins un variant d'épissage pour le traitement de troubles neurologiques. Des modèles de souris de troubles neurologiques présentant une expression accrue ou réduite de SRRM4 et/ou de SRRM3 sont également décrits.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)