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1. (WO2016094991) METHOD FOR PRODUCING PEGYLATED SILICA NANOPARTICLES AS CARRIERS OF HYDROPHOBIC PHARMACEUTICAL DRUGS, THUS OBTAINED NANOPARTICLES AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/094991    International Application No.:    PCT/BR2015/000202
Publication Date: 23.06.2016 International Filing Date: 16.12.2015
IPC:
C08G 77/06 (2006.01), C08G 77/04 (2006.01), A61K 9/51 (2006.01), A61K 47/30 (2006.01), A61K 47/04 (2006.01), A61K 31/121 (2006.01), A61K 31/4745 (2006.01), A61P 35/00 (2006.01)
Applicants: UNIVERSIDADE ESTADUAL DE CAMPINAS - UNICAMP [BR/BR]; Rua Roxo Moreira 1831 - Cidade Universitária "Zeferino Vaz" - Distrito de Barão Geraldo Caixa Postal 6.131 - Campinas - SP CEP 1 3083-970 (BR)
Inventors: ALVES, Oswaldo Luiz; (BR).
FONSECA, Leandro Carneiro; (BR).
DE PAULA, Amauri Jardim; (BR).
MARTINEZ, Diego Stefani Teodoro; (BR)
Agent: SILVADO, Fernanda Lavras Costallat; Rua Roxo Moreira 1831 . Cidade Universitária "Zeferino Vaz" - Distrito de Barão Geraldo Caixa Postal 6.131 CEP: 13083-970 - Campinas - SP (BR)
Priority Data:
BR 10 2014 031688 4 16.12.2014 BR
BR 13 2015 030941 3 10.12.2015 BR
Title (EN) METHOD FOR PRODUCING PEGYLATED SILICA NANOPARTICLES AS CARRIERS OF HYDROPHOBIC PHARMACEUTICAL DRUGS, THUS OBTAINED NANOPARTICLES AND USES THEREOF
(FR) PROCÉDÉ D'OBTENTION DE NANOPARTICULES DE SILICE PÉGYLÉES TRANSPORTEUSES D'AGENCES PHARMACEUTIQUES HYDROPHOBES, NANOPARTICULES AINSI OBTENUES ET LEURS UTILISATIONS
(PT) PROCESSO DE OBTENÇÃO DE NANOPARTICULAS DE SÍLICA PEGUILADAS CARREADORAS DE FÁRMACOS HIDROFÓBICOS, NANOPARTICULAS ASSIM OBTIDAS E SEUS USOS
Abstract: front page image
(EN)The present invention relates to a method for producing PEGylated silica nanoparticles as carriers of hydrophobic pharmaceutical drugs, to the silica nanoparticles obtained by this or other methods, and to the use thereof for the treatment of cancer. The nanoparticles effectively retain the pharmaceutical drug inside them, preventing the premature release of the drug in the external medium during intraveinous transport, reducing the collateral effects associated with chemotherapy and the dose concentration required for an antitumoral treatment.
(FR)La présente invention concerne un procédé d'obtention de nanoparticules de silice pégylées transporteuses de substances médicamenteuses hydrophobes, les nanoparticules de silice obtenues ou non au moyen dudit procédé et leur utilisation dans le traitement du cancer. La substance médicamenteuse peut être maintenue efficacement à l'intérieur desdites particules. On évite ainsi sa libération précoce dans le milieu extérieur pendant le transport intraveineux, d'où une réduction des effets secondaires associés à la chimiothérapie et une réduction de la concentration posologique nécessaire pour le traitement antitumoral.
(PT)A presente invenção refere-se a um processo de obtenção de nanoparticulas de sílica peguiladas carreadoras de fármacos hidrofóbicos, as nanoparticulas de sílicas obtidas ou não pelo dito processo e seu uso no tratamento do câncer. As nanoparticulas mantém efetivamente o fármaco em seu interior de modo. a evitar sua liberação precoce ao meio externo durante o transporte intravenoso, proporcionado redução de efeitos colaterais relacionados à quimioterapia e reduzindo a concentração necessária de dose para tratamento antitumoral.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Portuguese (PT)
Filing Language: Portuguese (PT)