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1. (WO2016094729) GLP-1 RECEPTOR MODULATORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/094729    International Application No.:    PCT/US2015/065109
Publication Date: 16.06.2016 International Filing Date: 10.12.2015
IPC:
C07D 403/12 (2006.01), C07D 215/14 (2006.01), C07D 231/12 (2006.01), C07D 401/04 (2006.01), C07D 401/06 (2006.01), C07D 401/12 (2006.01), C07D 403/04 (2006.01), C07D 237/08 (2006.01), C07D 239/26 (2006.01), C07D 407/12 (2006.01), C07D 409/12 (2006.01), C07D 409/14 (2006.01), C07D 239/74 (2006.01), C07D 413/04 (2006.01), C07D 413/12 (2006.01), C07D 241/12 (2006.01), C07D 417/12 (2006.01), C07D 471/04 (2006.01), C07D 253/06 (2006.01), C07D 207/08 (2006.01), C07D 271/06 (2006.01), C07D 495/04 (2006.01), C07D 295/084 (2006.01), C07D 295/135 (2006.01), C07D 213/55 (2006.01)
Applicants: CELGENE INTERNATIONAL II SARL [--/CH]; Rue des Moulins CH-2108 Couvet (CH)
Inventors: BOEHM, Marcus, F.; (US).
MARTINBOROUGH, Esther; (US).
MOORJANI, Manisha; (US).
TAMIYA, Junko; (US).
HUANG, Liming; (US).
YEAGER, Adam, R.; (US).
BRAHMACHARY, Enugurthi; (US).
FOWLER, Thomas; (GB).
NOVAK, Andrew; (GB).
MEGHANI, Premji; (GB).
KNAGGS, Michael; (GB).
GLYNN, Daniel; (GB).
MILLS, Mark; (GB)
Agent: HERMANNS, Karl, R.; (US)
Priority Data:
62/090,268 10.12.2014 US
62/161,658 14.05.2015 US
62/164,113 20.05.2015 US
Title (EN) GLP-1 RECEPTOR MODULATORS
(FR) NOUVEAUX MODULATEURS DU RÉCEPTEUR DU GLP-1
Abstract: front page image
(EN)Compounds are provided that modulate the glucagon-like peptide 1 (GLP-1) receptor, as well as methods of their synthesis, and methods of their therapeutic and/or prophylactic use. Such compounds can act as modulators or potentiators of GLP-1 receptor on their own, or with incretin peptides such as GLP-1(7-36) and GLP-1(9-36), or with peptide-based therapies, such as exenatide and liraglutide, and have the following general structure (where "^^^^" represents either or both the R and S form of the compound) (I) where A, B, C, Y1, Y2, Z, R1, R2, R3, R4, R5, W1, n, p and q are as defined herein.
(FR)L'invention concerne des composés qui modulent le récepteur du glucagon-like peptide 1 (GLP-1), ainsi que des procédés pour leur synthèse, et des procédés pour leur utilisation thérapeutique et/ou prophylactique. Lesdits composés peuvent agir comme modulateurs ou potentialisateurs du récepteur de GLP-1, seuls ou en association avec des incrétines telles que le GLP-1(7-36) et le GLP-1(9-36), ou dans des thérapies faisant intervenir des peptides, par exemple l'exénatide et le liraglutide, et ont la structure générale selon la formule (I) (où "^^^^" représente la forme R et/ou la forme S du composé), dans laquelle A, B, C, Y1, Y2, Z, R1, R2, R3, R4, R5, W1, n, p et q sont tels que définis dans la description.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)