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1. (WO2016094197) SPIROCYCLIC HETEROCYCLE COMPOUNDS USEFUL AS HIV INTEGRASE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/094197    International Application No.:    PCT/US2015/063850
Publication Date: 16.06.2016 International Filing Date: 04.12.2015
IPC:
A61K 31/4985 (2006.01)
Applicants: MERCK SHARP & DOHME CORP. [US/US]; 126 East Lincoln Avenue Rahway, NJ 07065-0907 (US) (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
EMBREY, Mark, W. [US/US]; (US) (US only).
GRAHAM, Thomas, H. [US/US]; (US) (US only).
RAHEEM, Izzat, T. [US/US]; (US) (US only).
SCHREIER, John, D. [US/US]; (US) (US only).
WADDELL, Sherman, T. [US/US]; (US) (US only).
WAI, John, S. [US/US]; (US) (US only).
HU, Lihong [CN/CN]; (CN) (NZ, US only).
PENG, Xuanjia [CN/CN]; (CN) (NZ, US only)
Inventors: EMBREY, Mark, W.; (US).
GRAHAM, Thomas, H.; (US).
RAHEEM, Izzat, T.; (US).
SCHREIER, John, D.; (US).
WADDELL, Sherman, T.; (US).
WAI, John, S.; (US).
HU, Lihong; (CN).
PENG, Xuanjia; (CN)
Common
Representative:
MERCK SHARP & DOHME CORP.; 126 East Lincoln Avenue Rahway, NJ 07065-0907 (US)
Priority Data:
PCT/CN2014/093335 09.12.2014 CN
Title (EN) SPIROCYCLIC HETEROCYCLE COMPOUNDS USEFUL AS HIV INTEGRASE INHIBITORS
(FR) COMPOSÉS HÉTÉROCYCLIQUES SPIROCYCLIQUES UTILES EN TANT QU'INHIBITEURS DE L'INTÉGRASE DU VIH
Abstract: front page image
(EN)The present invention relates to Spirocyclic Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, X, Y, R1, R2 and R4 are as defined herein. The present invention also relates to compositions comprising at least one Spirocyclic Heterocycle Compound, and methods of using the Spirocyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.
(FR)La présente invention concerne des composés hétérocycliques spirocycliques formule (I) et leurs sels de qualité pharmaceutique. Dans cette formule,A, B, X, Y, R1, R2 et R4 sont tels que définis dans la description. La présente invention concerne également des compositions contenant au moins un composé hétérocyclique spirocyclique, et des procédés d'utilisation de ces composés hétérocycliques spirocycliques pour traiter ou prévenir une infection par le VIH chez un patient.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)