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1. (WO2016093926) MIXED BED ION EXCHANGE ADSORBER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/093926    International Application No.:    PCT/US2015/053140
Publication Date: 16.06.2016 International Filing Date: 30.09.2015
IPC:
C07K 1/36 (2006.01), C07K 1/18 (2006.01), C07K 1/20 (2006.01)
Applicants: EMD MILLIPORE CORPORATION [US/US]; Emd Millipore Corporation 290 Concord Road Billerica, MA 01821 (US)
Inventors: STONE, Matthew, T.; (US).
AMARA, John, P.; (US)
Agent: MEHTANI, Sapna, Ph.D., J.D.; (US)
Priority Data:
62/089,030 08.12.2014 US
Title (EN) MIXED BED ION EXCHANGE ADSORBER
(FR) ADSORBANT POUR ÉCHANGE D'IONS À LITS MIXTES
Abstract: front page image
(EN)The present invention refers to new species of an ion exchange adsorber which is suitable for the separation of host cell proteins (HCPs), antibody fragments and low molecular weight substances from solutions containing antibodies. The invention especially refers to a process for purifying biological samples by separating biomolecules of interest and impurities, comprising steps of contacting a sample with said chromatography media consisting of fibers, said fibers having imparted thereon functionality enabling ion exchange chromatography and/or hydrophobic interaction.
(FR)La présente invention concerne un nouveau type d'adsorbant pour échange d'ions qui convient pour la séparation de protéines des cellules hôtes (HCP, pour "host cell proteins"), de fragments d'anticorps et de substances de faible poids moléculaire à partir de solutions contenant des anticorps. L'invention concerne, en particulier, un procédé de purification d'échantillons biologiques par séparation des biomolécules d'intérêt et des impuretés, comprenant les étapes consistant à mettre un échantillon en contact avec ledit substrat de chromatographie constitué de fibres, lesdites fibres lui ayant apporté une fonctionnalité permettant une chromatographie d'échange d'ions et/ou d'interaction hydrophobe.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)