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1. (WO2016093641) ANTIBACTERIAL COMPOSITION CONTAINING ADK PROTEIN AS ACTIVE INGREDIENT, OR COMPOSITION FOR PREVENTING OR TREATING SEPTICEMIA
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/093641    International Application No.:    PCT/KR2015/013521
Publication Date: 16.06.2016 International Filing Date: 10.12.2015
IPC:
A61K 38/16 (2006.01), A61P 31/04 (2006.01), A61K 48/00 (2006.01), A61P 31/00 (2006.01)
Applicants: KONKUK UNIVERSITY GLOCAL INDUSTRY-ACADEMIC COLLABORATION FOUNDATION [KR/KR]; 268, Chungwon-daero Chungju-si Chungcheongbuk-do 27478 (KR)
Inventors: PARK, Yeong Min; (KR).
JUNG, In Duk; (KR).
LIM, Yong Taik; (KR).
PARK, Jung Hee; (KR).
SHIN, Sung Jae; (KR)
Agent: KIM, Soon Woong; (KR)
Priority Data:
10-2014-0177329 10.12.2014 KR
10-2014-0177352 10.12.2014 KR
Title (EN) ANTIBACTERIAL COMPOSITION CONTAINING ADK PROTEIN AS ACTIVE INGREDIENT, OR COMPOSITION FOR PREVENTING OR TREATING SEPTICEMIA
(FR) COMPOSITION ANTIBACTÉRIENNE CONTENANT UNE PROTÉINE ADK UTILISÉE COMME PRINCIPE ACTIF, OU COMPOSITION POUR LA PRÉVENTION OU LE TRAITEMENT D'UNE SEPTICÉMIE
(KO) ADK 단백질을 유효성분으로 포함하는 항균용 조성물, 또는 패혈증의 예방 또는 치료용 조성물
Abstract: front page image
(EN)The present invention relates to an antibacterial composition containing, as an active ingredient, adenylate kinase or adenosine kinase (ADK) protein derived from Mycobacterium tuberculosis, and a composition for preventing or treating infectious diseases. In addition, the present invention relates to a composition for preventing or treating septicemia or septic shock, the composition containing, as active ingredients, the ADK protein and an antibiotic agent. The ADK protein derived from Mycobacterium tuberculosis according to the present invention has excellent antibacterial activity selectively against gram-negative bacteria, and thus can be favorably used as an antibacterial composition against gram-negative bacteria or for the prevention or treatment of infectious diseases caused by gram-negative bacteria. In addition, the ADK protein according to the present invention has excellent effects of inhibiting bacterial proliferation and removing endotoxin isolated from dead bacteria, thereby minimizing side effects caused by antibiotic agents when used in combination with the antibiotic agents, and has a significantly excellent septicemia treatment effect compared with single administration, thus can be favorably used for the prevention or treatment of septicemia or septic shock.
(FR)La présente invention concerne une composition antibactérienne contenant une protéine adénylate kinase ou adénosine kinase (ADK), utilisée comme principe actif, dérivée de Mycobacterium tuberculosis, et une composition destinée à prévenir ou à traiter des maladies infectieuses. De plus, la présente invention concerne une composition destinée à prévenir ou à traiter une septicémie ou un choc septique, ladite composition contenant la protéine ADK et un agent antibiotique, utilisés comme principes actifs. La protéine ADK dérivée de Mycobacterium tuberculosis selon la présente invention présente une excellente activité antibactérienne dirigée sélectivement contre les bactéries Gram négatif, et peut donc être avantageusement utilisée comme composition antibactérienne dirigée contre des bactéries Gram négatif ou pour la prévention ou le traitement de maladies infectieuses provoquées par des bactéries Gram négatif. En outre, la protéine ADK selon la présente invention présente d'excellents effets d'inhibition de la prolifération bactérienne et d'élimination de l'endotoxine isolée de bactéries mortes, ce qui permet de réduire au minimum les effets secondaires provoqués par des agents antibiotiques lorsqu'elle est utilisée en association avec des agents antibiotiques, et présente un effet de traitement de la septicémie qui est excellent de manière significative par comparaison avec une administration unique, qui peut ainsi être avantageusement utilisé pour la prévention ou le traitement d'une septicémie ou d'un choc septique.
(KO)본 발명은 마이코박테리움 튜버큘로시스(Mycobacterium tuberculosis) 유래의 ADK(Adenylate Kinase, Adenosine Kinase) 단백질을 유효성분으로 포함하는 항균용 조성물 및 감염성 질환의 예방 또는 치료용 조성물에 관한 것이다. 또한 본 발명은 상기 ADK 단백질 및 항생제를 유효성분으로 포함하는 패혈증 또는 패혈증성 쇼크의 예방 또는 치료용 조성물에 관한 것이다. 본 발명에 따른 마이코박테리움 튜버큘로시스(Mycobacterium tuberculosis) 유래의 ADK 단백질은 그람음성균에 대해 선택적으로 우수한 항균 활성을 가지고 있어, 그람음성균에 대한 항균용 조성물 또는 그람음성균에 의해 유발되는 감염성 질환의 예방 또는 치료에 유용하게 이용될 수 있다. 또한, 본 발명에 따른 ADK 단백질은 박테리아의 증식 억제뿐 아니라, 죽은 박테리아로부터 분리된 내독소를 제거하는 우수한 효과를 가지고 있어 항생제와 병용할 경우 항생제에 의한 부작용을 최소화할 수 있으며, 단독 투여에 비해 현저하게 우수한 패혈증 치료 효과를 가지고 있어, 패혈증 또는 패혈증성 쇼크의 예방 또는 치료에 유용하게 이용할 수 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)