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1. (WO2016093554) NOVEL 4-(ARYL)-N-(2-ALKOXYTHIENO[3,2-B]PYRAZIN-3-YL)-PIPERAZINE-1-CARBOXAMIDE DERIVATIVE, AND ANTIPROLIFERATIVE EFFECT THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/093554    International Application No.:    PCT/KR2015/013150
Publication Date: 16.06.2016 International Filing Date: 03.12.2015
IPC:
C07D 403/12 (2006.01), C07D 495/04 (2006.01), A61K 31/497 (2006.01), A61P 35/00 (2006.01)
Applicants: DONGGUK UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION [KR/KR]; 30, Pildong-ro 1-gil, Jung-gu, Seoul 04620 (KR)
Inventors: GONG, Young Dae; (KR).
KWAK, Se Hun; (KR).
LEE, Eun Sil; (KR)
Agent: SON, Min; (KR)
Priority Data:
10-2014-0175121 08.12.2014 KR
Title (EN) NOVEL 4-(ARYL)-N-(2-ALKOXYTHIENO[3,2-B]PYRAZIN-3-YL)-PIPERAZINE-1-CARBOXAMIDE DERIVATIVE, AND ANTIPROLIFERATIVE EFFECT THEREOF
(FR) NOUVEAU DÉRIVÉ DE 4-(ARYL)-N-(2-ALKOXYTHIÉNO[3,2-B]PYRAZIN-3-YL)-PIPÉRAZINE-1-CARBOXAMIDE ET EFFET ANTIPROLIFÉRATIF DE CELUI-CI
(KO) 신규한 4-(아릴)-N-(2-알콕시티에노[3,2-B]피라진-3-일)-피페라진-1-카복스아미드 유도체 및 이의 항증식 효과
Abstract: front page image
(EN)The present invention relates to: a novel 4-(aryl)-N-(2-alkoxythieno[3,2-b]pyrazin-3-yl)-piperazine-1-carboxamide derivative compound useful in the prevention or treatment of cancer; a preparation method therefor; and a pharmaceutical composition containing the same. The novel 4-(aryl)-N-(2-alkoxythieno[3,2-b]pyrazin-3-yl)-piperazine-1-carboxamide derivative compound of the present invention can effectively inhibit the growth of proliferating cells, and thus can be useful in the prevention or treatment of cancer.
(FR)La présente invention concerne : un nouveau composé dérivé de 4-(aryl)-N-(2-alkoxythiéno[3,2-b]pyrazin-3-yl)-pipérazine-1-carboxamide utile dans la prévention ou le traitement du cancer ; un procédé de préparation associé ; et une composition pharmaceutique le contenant. Le nouveau composé dérivé de 4-(aryl)-N-(2-alkoxythiéno[3,2-b]pyrazin-3-yl)-pipérazine-1-carboxamide selon la présente invention peut efficacement inhiber la croissance de cellules en prolifération, et peut donc être utile dans la prévention ou le traitement du cancer.
(KO)본 발명은 암의 예방 또는 치료에 유용하게 사용할 수 있는, 신규한 4-(아릴)-N-(2-알콕시티에노[3,2-b]피라진-3-일)-피페라진-1-카복스아미드 유도체 화합물, 이의 제조방법 및 이를 포함하는 약학적 조성물에 관한 것이다. 본 발명의 신규한 4-(아릴)-N-(2-알콕시티에노[3,2-b]피라진-3-일)-피페라진-1-카복스아미드 유도체 화합물은 증식성 세포 성장을 효과적으로 억제할 수 있으므로, 암의 예방 또는 치료에 유용하게 사용될 수 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)