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Machine translation
1. (WO2016092555) ISOLATED PHOSPHOTRIESTERASE POLYPEPTIDES, POLYNUCLEOTIDES ENCODING SAME AND USES THEREOF IN TREATING OR PREVENTING ORGANOPHOSPHATE EXPOSURE ASSOCIATED DAMAGE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/092555    International Application No.:    PCT/IL2015/051203
Publication Date: 16.06.2016 International Filing Date: 10.12.2015
IPC:
C12N 9/16 (2006.01)
Applicants: YEDA RESEARCH AND DEVELOPMENT CO. LTD. [IL/IL]; at the Weizmann Institute of Science P.O. Box 95 7610002 Rehovot (IL).
UNIVERSITY OF WASHINGTON [US/US]; 4311 11th Avenue NE, Suite 500 Seattle, Washington 98105 (US)
Inventors: TAWFIK, Dan S.; (IL).
LEADER, Haim; (IL).
ASHANI, Yaacov; (IL).
CHERNY, Izhack; (IL).
GOLDSMITH, Moshe; (IL).
GREISEN, Per Jr.; (US).
KHARE, Sagar D.; (US).
OBERDORFER, Gustav; (US).
BAKER, David; (US).
FLEISHMAN, Sarel; (IL).
GOLDENZWEIG, Adi; (IL).
AGGARWAL, Nidhi; (IL)
Agent: EHRLICH, Gal; (IL)
Priority Data:
62/090,411 11.12.2014 US
Title (EN) ISOLATED PHOSPHOTRIESTERASE POLYPEPTIDES, POLYNUCLEOTIDES ENCODING SAME AND USES THEREOF IN TREATING OR PREVENTING ORGANOPHOSPHATE EXPOSURE ASSOCIATED DAMAGE
(FR) POLYPEPTIDES DE PHOSPHOTRIESTÉRASE ISOLÉS, POLYNUCLÉOTIDES CODANT POUR CEUX-CI ET UTILISATIONS DE CEUX-CI DANS LE TRAITEMENT OU LA PRÉVENTION DES DOMMAGES ASSOCIÉS À L'EXPOSITION AUX ORGANOPHOSPHATES
Abstract: front page image
(EN)A genetically modified polypeptide is disclosed which comprises an amino acid sequence of phosphotriesterase (PTE) having at least twice the catalytic efficiency for a V-type nerve agent as a polypeptide which consists of the sequence as set forth in SEQ ID NO: 1, when assayed under identical conditions.
(FR)L'invention concerne un polypeptide génétiquement modifié comprenant une séquence d'acides aminés de phosphotriestérase (PTE) ayant au moins le double de l'efficacité catalytique pour un agent neurotoxique de type en V, par rapport à un polypeptide composé de la séquence telle que présentée dans SEQ ID NO : 1, lorsque testé dans des conditions identiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)
Licensing availability request The applicant has requested the International Bureau to indicate the availability for licensing purposes of the invention(s) claimed in this international application