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1. (WO2016092002) 1,2,4-TRIAZOLO[4,3-A]PYRIDINE COMPOUNDS AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS

Pub. No.:    WO/2016/092002    International Application No.:    PCT/EP2015/079216
Publication Date: Jun 16, 2016 International Filing Date: Dec 10, 2015
IPC: C07D 471/04
A61P 25/00
A61K 31/437
Applicants: JANSSEN PHARMACEUTICA NV
Inventors: CID-NÚÑEZ, José, Maria
Title: 1,2,4-TRIAZOLO[4,3-A]PYRIDINE COMPOUNDS AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
Abstract:
The present invention relates to novel 1,2,4-triazolo[4,3-a]pyridine compounds of formula (I) as positive allosteric modulators (PAMs) of the metabotropic glutamate receptor subtype 2 ("mGluR2"). The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention or treatment of disorders in which mGluR2 subtype of metabotropic receptors is involved.